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Overview

Uniprot IDP33981
Protein NameDual specificity protein kinase TTK
Gene NameTTK
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
19 TIDSIMNKVRDIKNK
298 SVVPCFMKRQTSRSE
392 KQWQSKRKSECINQN

Function

Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839)

Protein Sequence

10 MESEDLSGRE 20 LTIDSIMNKV 30 RDIKNKFKNE 40 DLTDELSLNK 50 ISADTTDNSG 60 TVNQIMMMAN 70 NPEDWLSLLL 80 KLEKNSVPLS 90 DALLNKLIGR 100 YSQAIEALPP 110 DKYGQNESFA 120 RIQVRFAELK 130 AIQEPDDARD 140 YFQMARANCK 150 KFAFVHISFA 160 QFELSQGNVK 170 KSKQLLQKAV 180 ERGAVPLEML 190 EIALRNLNLQ 200 KKQLLSEEEK 210 KNLSASTVLT 220 AQESFSGSLG 230 HLQNRNNSCD 240 SRGQTTKARF 250 LYGENMPPQD 260 AEIGYRNSLR 270 QTNKTKQSCP 280 FGRVPVNLLN 290 SPDCDVKTDD 300 SVVPCFMKRQ 310 TSRSECRDLV 320 VPGSKPSGND 330 SCELRNLKSV 340 QNSHFKEPLV 350 SDEKSSELII 360 TDSITLKNKT 370 ESSLLAKLEE 380 TKEYQEPEVP 390 ESNQKQWQSK 400 RKSECINQNP 410 AASSNHWQIP 420 ELARKVNTEQ 430 KHTTFEQPVF 440 SVSKQSPPIS 450 TSKWFDPKSI 460 CKTPSSNTLD 470 DYMSCFRTPV 480 VKNDFPPACQ 490 LSTPYGQPAC 500 FQQQQHQILA 510 TPLQNLQVLA 520 SSSANECISV 530 KGRIYSILKQ 540 IGSGGSSKVF 550 QVLNEKKQIY 560 AIKYVNLEEA 570 DNQTLDSYRN 580 EIAYLNKLQQ 590 HSDKIIRLYD 600 YEITDQYIYM 610 VMECGNIDLN 620 SWLKKKKSID 630 PWERKSYWKN 640 MLEAVHTIHQ 650 HGIVHSDLKP 660 ANFLIVDGML 670 KLIDFGIANQ 680 MQPDTTSVVK 690 DSQVGTVNYM 700 PPEAIKDMSS 710 SRENGKSKSK 720 ISPKSDVWSL 730 GCILYYMTYG 740 KTPFQQIINQ 750 ISKLHAIIDP 760 NHEIEFPDIP 770 EKDLQDVLKC 780 CLKRDPKQRI 790 SIPELLAHPY 800 VQIQTHPVNQ 810 MAKGTTEEMK 820 YVLGQLVGLN 830 SPNSILKAAK 840 TLYEHYSGGE 850 SHNSSSSKTF EKKRGKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005819 spindle
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0106310 protein serine kinase activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
Molecular Function GO:0004712 protein serine/threonine/tyrosine kinase activity
Molecular Function GO:0004713 protein tyrosine kinase activity
Biological Process GO:0007059 chromosome segregation
Biological Process GO:0033316 meiotic spindle assembly checkpoint signaling
Biological Process GO:0007094 mitotic spindle assembly checkpoint signaling
Biological Process GO:0007052 mitotic spindle organization
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0060391 positive regulation of SMAD protein signal transduction
Biological Process GO:0034501 protein localization to kinetochore
Biological Process GO:0140273 repair of mitotic kinetochore microtubule attachment defect
Biological Process GO:0007051 spindle organization

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.