Overview
| Uniprot ID | P33993 |
|---|
| Protein Name | DNA replication licensing factor MCM7 |
|---|
| Gene Name | MCM7 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 596 |
RREAWASKDATYTSA |
Function
Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage
Protein Sequence
10
MALKDYALEK
20
EKVKKFLQEF
30
YQDDELGKKQ
40
FKYGNQLVRL
50
AHREQVALYV
60
DLDDVAEDDP
70
ELVDSICENA
80
RRYAKLFADA
90
VQELLPQYKE
100
REVVNKDVLD
110
VYIEHRLMME
120
QRSRDPGMVR
130
SPQNQYPAEL
140
MRRFELYFQG
150
PSSNKPRVIR
160
EVRADSVGKL
170
VTVRGIVTRV
180
SEVKPKMVVA
190
TYTCDQCGAE
200
TYQPIQSPTF
210
MPLIMCPSQE
220
CQTNRSGGRL
230
YLQTRGSRFI
240
KFQEMKMQEH
250
SDQVPVGNIP
260
RSITVLVEGE
270
NTRIAQPGDH
280
VSVTGIFLPI
290
LRTGFRQVVQ
300
GLLSETYLEA
310
HRIVKMNKSE
320
DDESGAGELT
330
REELRQIAEE
340
DFYEKLAASI
350
APEIYGHEDV
360
KKALLLLLVG
370
GVDQSPRGMK
380
IRGNINICLM
390
GDPGVAKSQL
400
LSYIDRLAPR
410
SQYTTGRGSS
420
GVGLTAAVLR
430
DSVSGELTLE
440
GGALVLADQG
450
VCCIDEFDKM
460
AEADRTAIHE
470
VMEQQTISIA
480
KAGILTTLNA
490
RCSILAAANP
500
AYGRYNPRRS
510
LEQNIQLPAA
520
LLSRFDLLWL
530
IQDRPDRDND
540
LRLAQHITYV
550
HQHSRQPPSQ
560
FEPLDMKLMR
570
RYIAMCREKQ
580
PMVPESLADY
590
ITAAYVEMRR
600
EAWASKDATY
610
TSARTLLAIL
620
RLSTALARLR
630
MVDVVEKEDV
640
NEAIRLMEMS
650
KDSLLGDKGQ
660
TARTQRPADV
670
IFATVRELVS
680
GGRSVRFSEA
690
EQRCVSRGFT
700
PAQFQAALDE
710
YEELNVWQVN
ASRTRITFV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0000781 |
chromosome, telomeric region |
| Cellular Component |
GO:0071162 |
CMG complex |
| Cellular Component |
GO:0042555 |
MCM complex |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0003678 |
DNA helicase activity |
| Molecular Function |
GO:0003697 |
single-stranded DNA binding |
| Biological Process |
GO:0071364 |
cellular response to epidermal growth factor stimulus |
| Biological Process |
GO:0006974 |
DNA damage response |
| Biological Process |
GO:0006260 |
DNA replication |
| Biological Process |
GO:0006270 |
DNA replication initiation |
| Biological Process |
GO:0006271 |
DNA strand elongation involved in DNA replication |
| Biological Process |
GO:0000727 |
double-strand break repair via break-induced replication |
| Biological Process |
GO:0030174 |
regulation of DNA-templated DNA replication initiation |
| Biological Process |
GO:0042325 |
regulation of phosphorylation |
| Biological Process |
GO:0009410 |
response to xenobiotic stimulus |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.