Search Results

Overview

Uniprot IDP34913
Protein NameBifunctional epoxide hydrolase 2
Gene NameEPHX2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
43 LLNDAFQKGGPEGAT
483 ACKSLGRKILIPALM
73 LMEENCRKCSETAKV
79 RKCSETAKVCLPKNF
84 TAKVCLPKNFSIKEI
94 SIKEIFDKAISARKI

Function

Bifunctional enzyme (PubMed:12574510). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12574510, PubMed:12869654, PubMed:22798687). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:12574510, PubMed:12869654, PubMed:21217101, PubMed:22798687)

Protein Sequence

10 MTLRAAVFDL 20 DGVLALPAVF 30 GVLGRTEEAL 40 ALPRGLLNDA 50 FQKGGPEGAT 60 TRLMKGEITL 70 SQWIPLMEEN 80 CRKCSETAKV 90 CLPKNFSIKE 100 IFDKAISARK 110 INRPMLQAAL 120 MLRKKGFTTA 130 ILTNTWLDDR 140 AERDGLAQLM 150 CELKMHFDFL 160 IESCQVGMVK 170 PEPQIYKFLL 180 DTLKASPSEV 190 VFLDDIGANL 200 KPARDLGMVT 210 ILVQDTDTAL 220 KELEKVTGIQ 230 LLNTPAPLPT 240 SCNPSDMSHG 250 YVTVKPRVRL 260 HFVELGSGPA 270 VCLCHGFPES 280 WYSWRYQIPA 290 LAQAGYRVLA 300 MDMKGYGESS 310 APPEIEEYCM 320 EVLCKEMVTF 330 LDKLGLSQAV 340 FIGHDWGGML 350 VWYMALFYPE 360 RVRAVASLNT 370 PFIPANPNMS 380 PLESIKANPV 390 FDYQLYFQEP 400 GVAEAELEQN 410 LSRTFKSLFR 420 ASDESVLSMH 430 KVCEAGGLFV 440 NSPEEPSLSR 450 MVTEEEIQFY 460 VQQFKKSGFR 470 GPLNWYRNME 480 RNWKWACKSL 490 GRKILIPALM 500 VTAEKDFVLV 510 PQMSQHMEDW 520 IPHLKRGHIE 530 DCGHWTQMDK 540 PTEVNQILIK 550 WLDSDARNPP VVSKM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005782 peroxisomal matrix
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0033885 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
Molecular Function GO:0004301 epoxide hydrolase activity
Molecular Function GO:0042577 lipid phosphatase activity
Molecular Function GO:0052642 lysophosphatidic acid phosphatase activity
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0016791 phosphatase activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0015643 toxic substance binding
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0016311 dephosphorylation
Biological Process GO:0097176 epoxide metabolic process
Biological Process GO:0046839 phospholipid dephosphorylation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0001558 regulation of cell growth
Biological Process GO:0090181 regulation of cholesterol metabolic process
Biological Process GO:0009636 response to toxic substance
Biological Process GO:0046272 stilbene catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.