Search Results

Overview

Uniprot IDP34932
Protein NameHeat shock 70 kDa protein 4
Gene NameHSPA4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
272 RLSQECEKLKKLMSA
274 SQECEKLKKLMSANA
331 VLEQTKLKKEDIYAV
388 AILSPAFKVREFSIT
477 QSDGSSSKVKVKVRV
53 RSIGAAAKSQVISNA
557 ETSQAGSKDKKMDQP
560 QAGSKDKKMDQPPQA
568 MDQPPQAKKAKVKTS
569 DQPPQAKKAKVKTST
573 QAKKAKVKTSTVDLP
61 SQVISNAKNTVQGFK
631 YVYEMRDKLSGEYEK
679 VDKLAELKNLGQPIK
68 KNTVQGFKRFHGRAF
686 KNLGQPIKIRFQESE
719 IISSFKNKEDQYDHL
773 KEIEAKIKELTSTCS
785 TCSPIISKPKPKVEP
789 IISKPKPKVEPPKEE

Function

No function data available.

Protein Sequence

10 MSVVGIDLGF 20 QSCYVAVARA 30 GGIETIANEY 40 SDRCTPACIS 50 FGPKNRSIGA 60 AAKSQVISNA 70 KNTVQGFKRF 80 HGRAFSDPFV 90 EAEKSNLAYD 100 IVQLPTGLTG 110 IKVTYMEEER 120 NFTTEQVTAM 130 LLSKLKETAE 140 SVLKKPVVDC 150 VVSVPCFYTD 160 AERRSVMDAT 170 QIAGLNCLRL 180 MNETTAVALA 190 YGIYKQDLPA 200 LEEKPRNVVF 210 VDMGHSAYQV 220 SVCAFNRGKL 230 KVLATAFDTT 240 LGGRKFDEVL 250 VNHFCEEFGK 260 KYKLDIKSKI 270 RALLRLSQEC 280 EKLKKLMSAN 290 ASDLPLSIEC 300 FMNDVDVSGT 310 MNRGKFLEMC 320 NDLLARVEPP 330 LRSVLEQTKL 340 KKEDIYAVEI 350 VGGATRIPAV 360 KEKISKFFGK 370 ELSTTLNADE 380 AVTRGCALQC 390 AILSPAFKVR 400 EFSITDVVPY 410 PISLRWNSPA 420 EEGSSDCEVF 430 SKNHAAPFSK 440 VLTFYRKEPF 450 TLEAYYSSPQ 460 DLPYPDPAIA 470 QFSVQKVTPQ 480 SDGSSSKVKV 490 KVRVNVHGIF 500 SVSSASLVEV 510 HKSEENEEPM 520 ETDQNAKEEE 530 KMQVDQEEPH 540 VEEQQQQTPA 550 ENKAESEEME 560 TSQAGSKDKK 570 MDQPPQAKKA 580 KVKTSTVDLP 590 IENQLLWQID 600 REMLNLYIEN 610 EGKMIMQDKL 620 EKERNDAKNA 630 VEEYVYEMRD 640 KLSGEYEKFV 650 SEDDRNSFTL 660 KLEDTENWLY 670 EDGEDQPKQV 680 YVDKLAELKN 690 LGQPIKIRFQ 700 ESEERPKLFE 710 ELGKQIQQYM 720 KIISSFKNKE 730 DQYDHLDAAD 740 MTKVEKSTNE 750 AMEWMNNKLN 760 LQNKQSLTMD 770 PVVKSKEIEA 780 KIKELTSTCS 790 PIISKPKPKV 800 EPPKEEQKNA 810 EQNGPVDGQG 820 DNPGPQAAEQ 830 GTDTAVPSDS 840 DKKLPEMDID

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000774 adenyl-nucleotide exchange factor activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Biological Process GO:0051131 chaperone-mediated protein complex assembly
Biological Process GO:0006457 protein folding
Biological Process GO:0030150 protein import into mitochondrial matrix
Biological Process GO:0006986 response to unfolded protein

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.