Search Results
Overview
| Uniprot ID | P35080 |
|---|---|
| Protein Name | Profilin-2 |
| Gene Name | PFN2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 69 | NGLTLGAKKCSVIRD |
| 91 | CTMDIRTKSQGGEPT |
Function
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG
Protein Sequence
10
MAGWQSYVDN
20
LMCDGCCQEA
30
AIVGYCDAKY
40
VWAATAGGVF
50
QSITPIEIDM
60
IVGKDREGFF
70
TNGLTLGAKK
80
CSVIRDSLYV
90
DGDCTMDIRT
100
KSQGGEPTYN
110
VAVGRAGRVL
120
VFVMGKEGVH
130
GGGLNKKAYS
140
MAKYLRDSGF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0003785 | actin monomer binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0098885 | modification of postsynaptic actin cytoskeleton |
| Biological Process | GO:0010633 | negative regulation of epithelial cell migration |
| Biological Process | GO:1900028 | negative regulation of ruffle assembly |
| Biological Process | GO:0032233 | positive regulation of actin filament bundle assembly |
| Biological Process | GO:0030838 | positive regulation of actin filament polymerization |
| Biological Process | GO:0051496 | positive regulation of stress fiber assembly |
| Biological Process | GO:0099140 | presynaptic actin cytoskeleton organization |
| Biological Process | GO:0099171 | presynaptic modulation of chemical synaptic transmission |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0030833 | regulation of actin filament polymerization |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.