Overview
| Uniprot ID | P35171 |
|---|
| Protein Name | Cytochrome c oxidase subunit 7A2, mitochondrial |
|---|
| Gene Name | Cox7a2 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 33 |
NKVPEKQKLFQEDNG |
Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Protein Sequence
10
MLRNVLALRQ
20
IAQRTISTTS
30
RRHFENKVPE
40
KQKLFQEDNG
50
MPVHLKGGTS
60
DALLYRATML
70
LTVGGTAYAI
80
YMLAMAAFPK
KQN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Biological Process |
GO:0006123 |
mitochondrial electron transport, cytochrome c to oxygen |
| Biological Process |
GO:0006119 |
oxidative phosphorylation |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
| Cellular Component |
GO:0098803 |
respiratory chain complex |
| Cellular Component |
GO:0045277 |
respiratory chain complex IV |
| Molecular Function |
GO:0016491 |
oxidoreductase activity |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.