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Overview

Uniprot IDP35213
Protein Name14-3-3 protein beta/alpha
Gene NameYwhab
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
11 DKSELVQKAKLAEQA
122 ESKVFYLKMKGDYFR
124 KVFYLKMKGDYFRYL
13 SELVQKAKLAEQAER
160 EAFEISKKEMQPTHP
5 ***MTMDKSELVQKA
51 NLLSVAYKNVVGARR
70 VISSIEQKTERNEKK
82 EKKQQMGKEYREKIE

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13

Protein Sequence

10 MTMDKSELVQ 20 KAKLAEQAER 30 YDDMAAAMKA 40 VTEQGHELSN 50 EERNLLSVAY 60 KNVVGARRSS 70 WRVISSIEQK 80 TERNEKKQQM 90 GKEYREKIEA 100 ELQDICSDVL 110 ELLDKYLILN 120 ATHAESKVFY 130 LKMKGDYFRY 140 LSEVASGDNK 150 QTTVSNSQQA 160 YQEAFEISKK 170 EMQPTHPIRL 180 GLALNFSVFY 190 YEILNSPEKA 200 CSLAKTAFDE 210 AIAELDTLNE 220 ESYKDSTLIM 230 QLLRDNLTLW 240 TSENQGDEGD AGEGEN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0042470 melanosome
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0017053 transcription repressor complex
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0051219 phosphoprotein binding
Molecular Function GO:0050815 phosphoserine residue binding
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0004860 protein kinase inhibitor activity
Molecular Function GO:0004864 protein phosphatase inhibitor activity
Molecular Function GO:0140311 protein sequestering activity
Molecular Function GO:0044877 protein-containing complex binding
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0045744 negative regulation of G protein-coupled receptor signaling pathway
Biological Process GO:0042308 negative regulation of protein import into nucleus
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006605 protein targeting
Biological Process GO:0007165 signal transduction

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.