Search Results

Overview

Uniprot IDP35222
Protein NameCatenin beta-1
Gene NameCTNNB1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
180 VMVHQLSKKEASRHA
335 MRTYTYEKLLWTTSR

Function

Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). Also acts as a coactivator for other transcription factors, such as NR5A2 (PubMed:22187462). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (PubMed:29910125). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed:18086858). Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization (PubMed:21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed:18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity)

Protein Sequence

10 MATQADLMEL 20 DMAMEPDRKA 30 AVSHWQQQSY 40 LDSGIHSGAT 50 TTAPSLSGKG 60 NPEEEDVDTS 70 QVLYEWEQGF 80 SQSFTQEQVA 90 DIDGQYAMTR 100 AQRVRAAMFP 110 ETLDEGMQIP 120 STQFDAAHPT 130 NVQRLAEPSQ 140 MLKHAVVNLI 150 NYQDDAELAT 160 RAIPELTKLL 170 NDEDQVVVNK 180 AAVMVHQLSK 190 KEASRHAIMR 200 SPQMVSAIVR 210 TMQNTNDVET 220 ARCTAGTLHN 230 LSHHREGLLA 240 IFKSGGIPAL 250 VKMLGSPVDS 260 VLFYAITTLH 270 NLLLHQEGAK 280 MAVRLAGGLQ 290 KMVALLNKTN 300 VKFLAITTDC 310 LQILAYGNQE 320 SKLIILASGG 330 PQALVNIMRT 340 YTYEKLLWTT 350 SRVLKVLSVC 360 SSNKPAIVEA 370 GGMQALGLHL 380 TDPSQRLVQN 390 CLWTLRNLSD 400 AATKQEGMEG 410 LLGTLVQLLG 420 SDDINVVTCA 430 AGILSNLTCN 440 NYKNKMMVCQ 450 VGGIEALVRT 460 VLRAGDREDI 470 TEPAICALRH 480 LTSRHQEAEM 490 AQNAVRLHYG 500 LPVVVKLLHP 510 PSHWPLIKAT 520 VGLIRNLALC 530 PANHAPLREQ 540 GAIPRLVQLL 550 VRAHQDTQRR 560 TSMGGTQQQF 570 VEGVRMEEIV 580 EGCTGALHIL 590 ARDVHNRIVI 600 RGLNTIPLFV 610 QLLYSPIENI 620 QRVAAGVLCE 630 LAQDKEAAEA 640 IEAEGATAPL 650 TELLHSRNEG 660 VATYAAAVLF 670 RMSEDKPQDY 680 KKRLSVELTS 690 SLFRTEPMAW 700 NETADLGLDI 710 GAQGEPLGYR 720 QDDPSYRSFH 730 SGGYGQDALG 740 MDPMMEHEMG 750 GHHPGADYPV 760 DGLPDLGHAQ 770 DLMDGLPPGD 780 SNQLAWFDTD L

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0045177 apical part of cell
Cellular Component GO:0016327 apicolateral plasma membrane
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0030877 beta-catenin destruction complex
Cellular Component GO:1990907 beta-catenin-TCF complex
Cellular Component GO:0070369 beta-catenin-TCF7L2 complex
Cellular Component GO:0005923 bicellular tight junction
Cellular Component GO:0016342 catenin complex
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0030054 cell junction
Cellular Component GO:0071944 cell periphery
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000791 euchromatin
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005916 fascia adherens
Cellular Component GO:0016600 flotillin complex
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0016328 lateral plasma membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0031528 microvillus membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0099092 postsynaptic density, intracellular component
Cellular Component GO:0045211 postsynaptic membrane
Cellular Component GO:0098831 presynaptic active zone cytoplasmic component
Cellular Component GO:0042734 presynaptic membrane
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0032993 protein-DNA complex
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Cellular Component GO:0034750 Scrib-APC-beta-catenin complex
Cellular Component GO:0000922 spindle pole
Cellular Component GO:0045202 synapse
Cellular Component GO:0005667 transcription regulator complex
Cellular Component GO:1990909 Wnt signalosome
Cellular Component GO:0030018 Z disc
Molecular Function GO:0045294 alpha-catenin binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0097718 disordered domain specific binding
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:1990226 histone methyltransferase binding
Molecular Function GO:0070411 I-SMAD binding
Molecular Function GO:0019900 kinase binding
Molecular Function GO:0030331 nuclear estrogen receptor binding
Molecular Function GO:0016922 nuclear receptor binding
Molecular Function GO:0019902 phosphatase binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0019903 protein phosphatase binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0005102 signaling receptor binding
Molecular Function GO:0046332 SMAD binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0001221 transcription coregulator binding
Molecular Function GO:0001222 transcription corepressor binding
Molecular Function GO:0044325 transmembrane transporter binding
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0034333 adherens junction assembly
Biological Process GO:0036520 astrocyte-dopaminergic neuron signaling
Biological Process GO:0060070 canonical Wnt signaling pathway
Biological Process GO:0007155 cell adhesion
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0044331 cell-cell adhesion mediated by cadherin
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0071681 cellular response to indole-3-methanol
Biological Process GO:0061550 cranial ganglion development
Biological Process GO:1904888 cranial skeletal system development
Biological Process GO:0035995 detection of muscle stretch
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:1990791 dorsal root ganglion development
Biological Process GO:1990403 embryonic brain development
Biological Process GO:0036023 embryonic skeletal limb joint morphogenesis
Biological Process GO:0061154 endothelial tube morphogenesis
Biological Process GO:0007173 epidermal growth factor receptor signaling pathway
Biological Process GO:0001837 epithelial to mesenchymal transition
Biological Process GO:0035315 hair cell differentiation
Biological Process GO:0030902 hindbrain development
Biological Process GO:0021854 hypothalamus development
Biological Process GO:0072497 mesenchymal stem cell differentiation
Biological Process GO:0060231 mesenchymal to epithelial transition
Biological Process GO:1904948 midbrain dopaminergic neuron differentiation
Biological Process GO:0016525 negative regulation of angiogenesis
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0045976 negative regulation of mitotic cell cycle, embryonic
Biological Process GO:0050768 negative regulation of neurogenesis
Biological Process GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
Biological Process GO:0033234 negative regulation of protein sumoylation
Biological Process GO:1990138 neuron projection extension
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0003151 outflow tract morphogenesis
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:1905555 positive regulation of blood vessel branching
Biological Process GO:0045597 positive regulation of cell differentiation
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0010718 positive regulation of epithelial to mesenchymal transition
Biological Process GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process
Biological Process GO:0034112 positive regulation of homotypic cell-cell adhesion
Biological Process GO:0002052 positive regulation of neuroblast proliferation
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Biological Process GO:1901331 positive regulation of odontoblast differentiation
Biological Process GO:0048643 positive regulation of skeletal muscle tissue development
Biological Process GO:0032212 positive regulation of telomere maintenance via telomerase
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0032968 positive regulation of transcription elongation by RNA polymerase II
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0034394 protein localization to cell surface
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0045765 regulation of angiogenesis
Biological Process GO:0090279 regulation of calcium ion import
Biological Process GO:0030997 regulation of centriole-centriole cohesion
Biological Process GO:0070602 regulation of centromeric sister chromatid cohesion
Biological Process GO:0010717 regulation of epithelial to mesenchymal transition
Biological Process GO:0048145 regulation of fibroblast proliferation
Biological Process GO:0072182 regulation of nephron tubule epithelial cell differentiation
Biological Process GO:0050767 regulation of neurogenesis
Biological Process GO:2000008 regulation of protein localization to cell surface
Biological Process GO:0031396 regulation of protein ubiquitination
Biological Process GO:0048660 regulation of smooth muscle cell proliferation
Biological Process GO:0051963 regulation of synapse assembly
Biological Process GO:0051884 regulation of timing of anagen
Biological Process GO:0032355 response to estradiol
Biological Process GO:0009410 response to xenobiotic stimulus
Biological Process GO:0019827 stem cell population maintenance
Biological Process GO:0061549 sympathetic ganglion development
Biological Process GO:0097091 synaptic vesicle clustering

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.