Overview
| Uniprot ID | P35226 |
|---|
| Protein Name | Polycomb complex protein BMI-1 |
|---|
| Gene Name | BMI1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 314 |
SFANRPRKSSVNGSS |
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:26151332, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:21772249, PubMed:26151332)
Protein Sequence
10
MHRTTRIKIT
20
ELNPHLMCVL
30
CGGYFIDATT
40
IIECLHSFCK
50
TCIVRYLETS
60
KYCPICDVQV
70
HKTRPLLNIR
80
SDKTLQDIVY
90
KLVPGLFKNE
100
MKRRRDFYAA
110
HPSADAANGS
120
NEDRGEVADE
130
DKRIITDDEI
140
ISLSIEFFDQ
150
NRLDRKVNKD
160
KEKSKEEVND
170
KRYLRCPAAM
180
TVMHLRKFLR
190
SKMDIPNTFQ
200
IDVMYEEEPL
210
KDYYTLMDIA
220
YIYTWRRNGP
230
LPLKYRVRPT
240
CKRMKISHQR
250
DGLTNAGELE
260
SDSGSDKANS
270
PAGGIPSTSS
280
CLPSPSTPVQ
290
SPHPQFPHIS
300
STMNGTSNSP
310
SGNHQSSFAN
320
RPRKSSVNGS
SATSSG
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0000792 |
heterochromatin |
| Cellular Component |
GO:0016604 |
nuclear body |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0031519 |
PcG protein complex |
| Cellular Component |
GO:0035102 |
PRC1 complex |
| Cellular Component |
GO:0000151 |
ubiquitin ligase complex |
| Molecular Function |
GO:1990841 |
promoter-specific chromatin binding |
| Molecular Function |
GO:0071535 |
RING-like zinc finger domain binding |
| Molecular Function |
GO:0097027 |
ubiquitin-protein transferase activator activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006338 |
chromatin remodeling |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0030097 |
hemopoiesis |
| Biological Process |
GO:0031507 |
heterochromatin formation |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:0045814 |
negative regulation of gene expression, epigenetic |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0030890 |
positive regulation of B cell proliferation |
| Biological Process |
GO:0048146 |
positive regulation of fibroblast proliferation |
| Biological Process |
GO:0033092 |
positive regulation of immature T cell proliferation in thymus |
| Biological Process |
GO:0051443 |
positive regulation of ubiquitin-protein transferase activity |
| Biological Process |
GO:0010468 |
regulation of gene expression |
| Biological Process |
GO:0007379 |
segment specification |
Reference
PMID: N/A