Search Results
Overview
| Uniprot ID | P35237 |
|---|---|
| Protein Name | Serpin B6 |
| Gene Name | SERPINB6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 132 | SAVEKSRKHINTWVA |
Function
May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss
Protein Sequence
10
MDVLAEANGT
20
FALNLLKTLG
30
KDNSKNVFFS
40
PMSMSCALAM
50
VYMGAKGNTA
60
AQMAQILSFN
70
KSGGGGDIHQ
80
GFQSLLTEVN
90
KTGTQYLLRM
100
ANRLFGEKSC
110
DFLSSFRDSC
120
QKFYQAEMEE
130
LDFISAVEKS
140
RKHINTWVAE
150
KTEGKIAELL
160
SPGSVDPLTR
170
LVLVNAVYFR
180
GNWDEQFDKE
190
NTEERLFKVS
200
KNEEKPVQMM
210
FKQSTFKKTY
220
IGEIFTQILV
230
LPYVGKELNM
240
IIMLPDETTD
250
LRTVEKELTY
260
EKFVEWTRLD
270
MMDEEEVEVS
280
LPRFKLEESY
290
DMESVLRNLG
300
MTDAFELGKA
310
DFSGMSQTDL
320
SLSKVVHKSF
330
VEVNEEGTEA
340
AAATAAIMMM
350
RCARFVPRFC
360
ADHPFLFFIQ
370
HSKTNGILFC
GRFSSP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0101003 | ficolin-1-rich granule membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0030667 | secretory granule membrane |
| Cellular Component | GO:0097180 | serine protease inhibitor complex |
| Cellular Component | GO:0070821 | tertiary granule membrane |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Biological Process | GO:0071470 | cellular response to osmotic stress |
| Biological Process | GO:0007605 | sensory perception of sound |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.