Search Results
Overview
| Uniprot ID | P35240 |
|---|---|
| Protein Name | Merlin |
| Gene Name | NF2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 579 | SKHNTIKKLTLQSAK |
Function
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex
Protein Sequence
10
MAGAIASRMS
20
FSSLKRKQPK
30
TFTVRIVTMD
40
AEMEFNCEMK
50
WKGKDLFDLV
60
CRTLGLRETW
70
FFGLQYTIKD
80
TVAWLKMDKK
90
VLDHDVSKEE
100
PVTFHFLAKF
110
YPENAEEELV
120
QEITQHLFFL
130
QVKKQILDEK
140
IYCPPEASVL
150
LASYAVQAKY
160
GDYDPSVHKR
170
GFLAQEELLP
180
KRVINLYQMT
190
PEMWEERITA
200
WYAEHRGRAR
210
DEAEMEYLKI
220
AQDLEMYGVN
230
YFAIRNKKGT
240
ELLLGVDALG
250
LHIYDPENRL
260
TPKISFPWNE
270
IRNISYSDKE
280
FTIKPLDKKI
290
DVFKFNSSKL
300
RVNKLILQLC
310
IGNHDLFMRR
320
RKADSLEVQQ
330
MKAQAREEKA
340
RKQMERQRLA
350
REKQMREEAE
360
RTRDELERRL
370
LQMKEEATMA
380
NEALMRSEET
390
ADLLAEKAQI
400
TEEEAKLLAQ
410
KAAEAEQEMQ
420
RIKATAIRTE
430
EEKRLMEQKV
440
LEAEVLALKM
450
AEESERRAKE
460
ADQLKQDLQE
470
AREAERRAKQ
480
KLLEIATKPT
490
YPPMNPIPAP
500
LPPDIPSFNL
510
IGDSLSFDFK
520
DTDMKRLSME
530
IEKEKVEYME
540
KSKHLQEQLN
550
ELKTEIEALK
560
LKERETALDI
570
LHNENSDRGG
580
SSKHNTIKKL
590
TLQSAKSRVA
FFEEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032587 | ruffle membrane |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0005178 | integrin binding |
| Molecular Function | GO:0035591 | signaling adaptor activity |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0035329 | hippo signaling |
| Biological Process | GO:0070306 | lens fiber cell differentiation |
| Biological Process | GO:0060243 | negative regulation of cell growth involved in contact inhibition |
| Biological Process | GO:0030336 | negative regulation of cell migration |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0022408 | negative regulation of cell-cell adhesion |
| Biological Process | GO:0001953 | negative regulation of cell-matrix adhesion |
| Biological Process | GO:0046426 | negative regulation of receptor signaling pathway via JAK-STAT |
| Biological Process | GO:2000643 | positive regulation of early endosome to late endosome transport |
| Biological Process | GO:1902966 | positive regulation of protein localization to early endosome |
| Biological Process | GO:0051496 | positive regulation of stress fiber assembly |
| Biological Process | GO:0042981 | regulation of apoptotic process |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:0014013 | regulation of gliogenesis |
| Biological Process | GO:0035330 | regulation of hippo signaling |
| Biological Process | GO:1902115 | regulation of organelle assembly |
| Biological Process | GO:0014010 | Schwann cell proliferation |
| Cellular Component | GO:0045177 | apical part of cell |
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0032154 | cleavage furrow |
| Cellular Component | GO:0030864 | cortical actin cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0031527 | filopodium membrane |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.