Search Results

Overview

Uniprot ID	P35241
Protein Name	Radixin
Gene Name	RDX
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
162	QRVLEQHKLTKEQWE
253	RNISFNDKKFVIKPI
258	NDKKFVIKPIDKKAP
262	FVIKPIDKKAPDFVF
263	VIKPIDKKAPDFVFY
327	RAQLENEKKKREIAE
344	KERIEREKEELMERL
363	EQTIKAQKELEEQTR
371	ELEEQTRKALELDQE
400	RRAAEEAKSAIAKQA
405	EAKSAIAKQAADQMK
436	ALLEEAKKKKEEEAT
526	QKNERVKKQLQALSS
544	QARDETKKTQNDVLH
556	VLHAENVKAGRDKYK

Function

Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane

Protein Sequence

10 MPKPINVRVT 20 TMDAELEFAI 30 QPNTTGKQLF 40 DQVVKTVGLR 50 EVWFFGLQYV 60 DSKGYSTWLK 70 LNKKVTQQDV 80 KKENPLQFKF 90 RAKFFPEDVS 100 EELIQEITQR 110 LFFLQVKEAI 120 LNDEIYCPPE 130 TAVLLASYAV 140 QAKYGDYNKE 150 IHKPGYLAND 160 RLLPQRVLEQ 170 HKLTKEQWEE 180 RIQNWHEEHR 190 GMLREDSMME 200 YLKIAQDLEM 210 YGVNYFEIKN 220 KKGTELWLGV 230 DALGLNIYEH 240 DDKLTPKIGF 250 PWSEIRNISF 260 NDKKFVIKPI 270 DKKAPDFVFY 280 APRLRINKRI 290 LALCMGNHEL 300 YMRRRKPDTI 310 EVQQMKAQAR 320 EEKHQKQLER 330 AQLENEKKKR 340 EIAEKEKERI 350 EREKEELMER 360 LKQIEEQTIK 370 AQKELEEQTR 380 KALELDQERK 390 RAKEEAERLE 400 KERRAAEEAK 410 SAIAKQAADQ 420 MKNQEQLAAE 430 LAEFTAKIAL 440 LEEAKKKKEE 450 EATEWQHKAF 460 AAQEDLEKTK 470 EELKTVMSAP 480 PPPPPPPVIP 490 PTENEHDEHD 500 ENNAEASAEL 510 SNEGVMNHRS 520 EEERVTETQK 530 NERVKKQLQA 540 LSSELAQARD 550 ETKKTQNDVL 560 HAENVKAGRD 570 KYKTLRQIRQ 580 GNTKQRIDEF EAM

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0045177	apical part of cell
Cellular Component	GO:0016324	apical plasma membrane
Cellular Component	GO:0071944	cell periphery
Cellular Component	GO:0032154	cleavage furrow
Cellular Component	GO:0030864	cortical actin cytoskeleton
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0030175	filopodium
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0005902	microvillus
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0001726	ruffle
Cellular Component	GO:0120044	stereocilium base
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0051117	ATPase binding
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0050839	cell adhesion molecule binding
Molecular Function	GO:0019904	protein domain specific binding
Molecular Function	GO:0051018	protein kinase A binding
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0051693	actin filament capping
Biological Process	GO:0097067	cellular response to thyroid hormone stimulus
Biological Process	GO:0061028	establishment of endothelial barrier
Biological Process	GO:0061951	establishment of protein localization to plasma membrane
Biological Process	GO:2000643	positive regulation of early endosome to late endosome transport
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0045732	positive regulation of protein catabolic process
Biological Process	GO:1902966	positive regulation of protein localization to early endosome
Biological Process	GO:0072659	protein localization to plasma membrane
Biological Process	GO:1903391	regulation of adherens junction organization
Biological Process	GO:0008360	regulation of cell shape
Biological Process	GO:1902115	regulation of organelle assembly
Biological Process	GO:0150054	regulation of postsynaptic neurotransmitter receptor diffusion trapping
Biological Process	GO:0032487	regulation of Rap protein signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.