Search Results
Overview
| Uniprot ID | P35270 |
|---|---|
| Protein Name | Sepiapterin reductase |
| Gene Name | SPR |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 226 | RKGLQELKAKGKLVD |
| 230 | QELKAKGKLVDCKVS |
| 247 | KLLSLLEKDEFKSGA |
| 90 | LRELPRPKGLQRLLL |
Function
Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin
Protein Sequence
10
MEGGLGRAVC
20
LLTGASRGFG
30
RTLAPLLASL
40
LSPGSVLVLS
50
ARNDEALRQL
60
EAELGAERSG
70
LRVVRVPADL
80
GAEAGLQQLL
90
GALRELPRPK
100
GLQRLLLINN
110
AGSLGDVSKG
120
FVDLSDSTQV
130
NNYWALNLTS
140
MLCLTSSVLK
150
AFPDSPGLNR
160
TVVNISSLCA
170
LQPFKGWALY
180
CAGKAARDML
190
FQVLALEEPN
200
VRVLNYAPGP
210
LDTDMQQLAR
220
ETSVDPDMRK
230
GLQELKAKGK
240
LVDCKVSAQK
250
LLSLLEKDEF
260
KSGAHVDFYD
K
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0008106 | alcohol dehydrogenase (NADP+) activity |
| Molecular Function | GO:0050661 | NADP binding |
| Molecular Function | GO:0004757 | sepiapterin reductase (NADP+) activity |
| Biological Process | GO:0006809 | nitric oxide biosynthetic process |
| Biological Process | GO:0006729 | tetrahydrobiopterin biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.