Overview
| Uniprot ID | P35435 |
|---|
| Protein Name | ATP synthase F(1) complex subunit gamma, mitochondrial |
|---|
| Gene Name | Atp5f1c |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 113 |
VGIGEKIKSILYRTH |
| 129 |
DQFLVSFKDVGRKPP |
| 237 |
TAMDNASKNASDMID |
| 245 |
NASDMIDKLTLTFNR |
| 30 |
MKMVAAAKYARAERE |
| 4 |
****ATLKDITRRLK |
| 54 |
GSLALYEKAEIKGPE |
| 58 |
LYEKAEIKGPEDKKK |
| 65 |
KGPEDKKKHLIIGVS |
| 87 |
AIHSSVAKQMKNDMA |
| 90 |
SSVAKQMKNDMAALT |
Function
Subunit gamma, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the central stalk subunit delta, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate (By similarity)
Protein Sequence
10
ATLKDITRRL
20
KSIKNIQKIT
30
KSMKMVAAAK
40
YARAERELKP
50
ARVYGTGSLA
60
LYEKAEIKGP
70
EDKKKHLIIG
80
VSSDRGLCGA
90
IHSSVAKQMK
100
NDMAALTAAG
110
KEVMIVGIGE
120
KIKSILYRTH
130
SDQFLVSFKD
140
VGRKPPTFGD
150
ASVIALELLN
160
SGYEFDEGSI
170
IFNQFKSVIS
180
YKTEEKPIFS
190
FSTVVAAENM
200
SIYDDIDADV
210
LQNYQEYNLA
220
NIIYYSLKES
230
TTSEQSARMT
240
AMDNASKNAS
250
DMIDKLTLTF
260
NRTRQAVITK
270
ELIEIISGAA
ALD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0045259 |
proton-transporting ATP synthase complex |
| Molecular Function |
GO:0046933 |
proton-transporting ATP synthase activity, rotational mechanism |
| Biological Process |
GO:0071732 |
cellular response to nitric oxide |
| Biological Process |
GO:0015986 |
proton motive force-driven ATP synthesis |
| Biological Process |
GO:0042776 |
proton motive force-driven mitochondrial ATP synthesis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.