Search Results
Overview
| Uniprot ID | P35439 |
|---|---|
| Protein Name | Glutamate receptor ionotropic, NMDA 1 |
| Gene Name | Grin1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 329 | KRVLMSSKYADGVTG |
| 37 | GAVLSTRKHEQMFRE |
Function
Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:1350383, PubMed:1388270, PubMed:1834949, PubMed:8428958). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the long-term potentiation (LTP) (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:11823786, PubMed:1350383, PubMed:1388270, PubMed:15996549, PubMed:18177891, PubMed:1834949, PubMed:24876489, PubMed:27135925, PubMed:27618671, PubMed:28384476, PubMed:28468946, PubMed:8428958). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 or GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:10436042, PubMed:11160393, PubMed:11929923, PubMed:28384476, PubMed:9463421). Forms excitatory glycinergic receptor complexes with GluN3 alone which are activated by glycine binding to the GluN1 and GluN3 subunits (PubMed:11823786, PubMed:11929923, PubMed:12391275)
Protein Sequence
10
MSTMHLLTFA
20
LLFSCSFARA
30
ACDPKIVNIG
40
AVLSTRKHEQ
50
MFREAVNQAN
60
KRHGSWKIQL
70
NATSVTHKPN
80
AIQMALSVCE
90
DLISSQVYAI
100
LVSHPPTPND
110
HFTPTPVSYT
120
AGFYRIPVLG
130
LTTRMSIYSD
140
KSIHLSFLRT
150
VPPYSHQSSV
160
WFEMMRVYNW
170
NHIILLVSDD
180
HEGRAAQKRL
190
ETLLEERESK
200
AEKVLQFDPG
210
TKNVTALLME
220
ARELEARVII
230
LSASEDDAAT
240
VYRAAAMLNM
250
TGSGYVWLVG
260
EREISGNALR
270
YAPDGIIGLQ
280
LINGKNESAH
290
ISDAVGVVAQ
300
AVHELLEKEN
310
ITDPPRGCVG
320
NTNIWKTGPL
330
FKRVLMSSKY
340
ADGVTGRVEF
350
NEDGDRKFAN
360
YSIMNLQNRK
370
LVQVGIYNGT
380
HVIPNDRKII
390
WPGGETEKPR
400
GYQMSTRLKI
410
VTIHQEPFVY
420
VKPTMSDGTC
430
KEEFTVNGDP
440
VKKVICTGPN
450
DTSPGSPRHT
460
VPQCCYGFCI
470
DLLIKLARTM
480
NFTYEVHLVA
490
DGKFGTQERV
500
NNSNKKEWNG
510
MMGELLSGQA
520
DMIVAPLTIN
530
NERAQYIEFS
540
KPFKYQGLTI
550
LVKKEIPRST
560
LDSFMQPFQS
570
TLWLLVGLSV
580
HVVAVMLYLL
590
DRFSPFGRFK
600
VNSEEEEEDA
610
LTLSSAMWFS
620
WGVLLNSGIG
630
EGAPRSFSAR
640
ILGMVWAGFA
650
MIIVASYTAN
660
LAAFLVLDRP
670
EERITGINDP
680
RLRNPSDKFI
690
YATVKQSSVD
700
IYFRRQVELS
710
TMYRHMEKHN
720
YESAAEAIQA
730
VRDNKLHAFI
740
WDSAVLEFEA
750
SQKCDLVTTG
760
ELFFRSGFGI
770
GMRKDSPWKQ
780
NVSLSILKSH
790
ENGFMEDLDK
800
TWVRYQECDS
810
RSNAPATLTF
820
ENMAGVFMLV
830
AGGIVAGIFL
840
IFIEIAYKRH
850
KDARRKQMQL
860
AFAAVNVWRK
870
NLQDRKSGRA
880
EPDPKKKATF
890
RAITSTLASS
900
FKRRRSSKDT
910
STGGGRGALQ
920
NQKDTVLPRR
930
AIEREEGQLQ
LCSRHRES
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0043195 | terminal bouton |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0005262 | calcium channel activity |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0016595 | glutamate binding |
| Molecular Function | GO:0035254 | glutamate receptor binding |
| Molecular Function | GO:0022849 | glutamate-gated calcium ion channel activity |
| Molecular Function | GO:0004970 | glutamate-gated receptor activity |
| Molecular Function | GO:0016594 | glycine binding |
| Molecular Function | GO:0015276 | ligand-gated monoatomic ion channel activity |
| Molecular Function | GO:0099507 | ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential |
| Molecular Function | GO:0015280 | ligand-gated sodium channel activity |
| Molecular Function | GO:0005261 | monoatomic cation channel activity |
| Molecular Function | GO:0004972 | NMDA glutamate receptor activity |
| Molecular Function | GO:0019902 | phosphatase binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0038023 | signaling receptor activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0022824 | transmitter-gated monoatomic ion channel activity |
| Molecular Function | GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential |
| Molecular Function | GO:0022843 | voltage-gated monoatomic cation channel activity |
| Biological Process | GO:0008344 | adult locomotory behavior |
| Biological Process | GO:0008306 | associative learning |
| Biological Process | GO:0055074 | calcium ion homeostasis |
| Biological Process | GO:0097553 | calcium ion transmembrane import into cytosol |
| Biological Process | GO:0070588 | calcium ion transmembrane transport |
| Biological Process | GO:0006816 | calcium ion transport |
| Biological Process | GO:1905430 | cellular response to glycine |
| Biological Process | GO:0071287 | cellular response to manganese ion |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0001661 | conditioned taste aversion |
| Biological Process | GO:0060079 | excitatory postsynaptic potential |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0035235 | ionotropic glutamate receptor signaling pathway |
| Biological Process | GO:0007612 | learning |
| Biological Process | GO:0007611 | learning or memory |
| Biological Process | GO:0007616 | long-term memory |
| Biological Process | GO:0060179 | male mating behavior |
| Biological Process | GO:0007613 | memory |
| Biological Process | GO:0098655 | monoatomic cation transmembrane transport |
| Biological Process | GO:0006812 | monoatomic cation transport |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0050905 | neuromuscular process |
| Biological Process | GO:0008355 | olfactory learning |
| Biological Process | GO:0021586 | pons maturation |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0010524 | positive regulation of calcium ion transport into cytosol |
| Biological Process | GO:1902952 | positive regulation of dendritic spine maintenance |
| Biological Process | GO:2000463 | positive regulation of excitatory postsynaptic potential |
| Biological Process | GO:1903428 | positive regulation of reactive oxygen species biosynthetic process |
| Biological Process | GO:1900149 | positive regulation of Schwann cell migration |
| Biological Process | GO:0051968 | positive regulation of synaptic transmission, glutamatergic |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0060134 | prepulse inhibition |
| Biological Process | GO:0018964 | propylene metabolic process |
| Biological Process | GO:0051290 | protein heterotetramerization |
| Biological Process | GO:1903539 | protein localization to postsynaptic membrane |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0050770 | regulation of axonogenesis |
| Biological Process | GO:0010646 | regulation of cell communication |
| Biological Process | GO:0048814 | regulation of dendrite morphogenesis |
| Biological Process | GO:0048169 | regulation of long-term neuronal synaptic plasticity |
| Biological Process | GO:0042391 | regulation of membrane potential |
| Biological Process | GO:1904062 | regulation of monoatomic cation transmembrane transport |
| Biological Process | GO:0043523 | regulation of neuron apoptotic process |
| Biological Process | GO:0048168 | regulation of neuronal synaptic plasticity |
| Biological Process | GO:0043576 | regulation of respiratory gaseous exchange |
| Biological Process | GO:0051963 | regulation of synapse assembly |
| Biological Process | GO:0048167 | regulation of synaptic plasticity |
| Biological Process | GO:0014075 | response to amine |
| Biological Process | GO:0001975 | response to amphetamine |
| Biological Process | GO:0051592 | response to calcium ion |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0060992 | response to fungicide |
| Biological Process | GO:1905429 | response to glycine |
| Biological Process | GO:1903416 | response to glycoside |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0043278 | response to morphine |
| Biological Process | GO:0048511 | rhythmic process |
| Biological Process | GO:0019233 | sensory perception of pain |
| Biological Process | GO:0035176 | social behavior |
| Biological Process | GO:0035725 | sodium ion transmembrane transport |
| Biological Process | GO:0001964 | startle response |
| Biological Process | GO:0001967 | suckling behavior |
| Biological Process | GO:0035249 | synaptic transmission, glutamatergic |
| Biological Process | GO:0008542 | visual learning |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0032590 | dendrite membrane |
| Cellular Component | GO:0044307 | dendritic branch |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0060076 | excitatory synapse |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0098686 | hippocampal mossy fiber to CA3 synapse |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0098878 | neurotransmitter receptor complex |
| Cellular Component | GO:0017146 | NMDA selective glutamate receptor complex |
| Cellular Component | GO:0098688 | parallel fiber to Purkinje cell synapse |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0098839 | postsynaptic density membrane |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Cellular Component | GO:0048787 | presynaptic active zone membrane |
| Cellular Component | GO:0042734 | presynaptic membrane |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0043083 | synaptic cleft |
| Cellular Component | GO:0097060 | synaptic membrane |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.