Overview
| Uniprot ID | P35443 |
|---|
| Protein Name | Thrombospondin-4 |
|---|
| Gene Name | THBS4 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 246 |
DLLRQQVKETSFLRN |
Function
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity)
Protein Sequence
10
MLAPRGAAVL
20
LLHLVLQRWL
30
AAGAQATPQV
40
FDLLPSSSQR
50
LNPGALLPVL
60
TDPALNDLYV
70
ISTFKLQTKS
80
SATIFGLYSS
90
TDNSKYFEFT
100
VMGRLNKAIL
110
RYLKNDGKVH
120
LVVFNNLQLA
130
DGRRHRILLR
140
LSNLQRGAGS
150
LELYLDCIQV
160
DSVHNLPRAF
170
AGPSQKPETI
180
ELRTFQRKPQ
190
DFLEELKLVV
200
RGSLFQVASL
210
QDCFLQQSEP
220
LAATGTGDFN
230
RQFLGQMTQL
240
NQLLGEVKDL
250
LRQQVKETSF
260
LRNTIAECQA
270
CGPLKFQSPT
280
PSTVVPPAPP
290
APPTRPPRRC
300
DSNPCFRGVQ
310
CTDSRDGFQC
320
GPCPEGYTGN
330
GITCIDVDEC
340
KYHPCYPGVH
350
CINLSPGFRC
360
DACPVGFTGP
370
MVQGVGISFA
380
KSNKQVCTDI
390
DECRNGACVP
400
NSICVNTLGS
410
YRCGPCKPGY
420
TGDQIRGCKA
430
ERNCRNPELN
440
PCSVNAQCIE
450
ERQGDVTCVC
460
GVGWAGDGYI
470
CGKDVDIDSY
480
PDEELPCSAR
490
NCKKDNCKYV
500
PNSGQEDADR
510
DGIGDACDED
520
ADGDGILNEQ
530
DNCVLIHNVD
540
QRNSDKDIFG
550
DACDNCLSVL
560
NNDQKDTDGD
570
GRGDACDDDM
580
DGDGIKNILD
590
NCPKFPNRDQ
600
RDKDGDGVGD
610
ACDSCPDVSN
620
PNQSDVDNDL
630
VGDSCDTNQD
640
SDGDGHQDST
650
DNCPTVINSA
660
QLDTDKDGIG
670
DECDDDDDND
680
GIPDLVPPGP
690
DNCRLVPNPA
700
QEDSNSDGVG
710
DICESDFDQD
720
QVIDRIDVCP
730
ENAEVTLTDF
740
RAYQTVVLDP
750
EGDAQIDPNW
760
VVLNQGMEIV
770
QTMNSDPGLA
780
VGYTAFNGVD
790
FEGTFHVNTQ
800
TDDDYAGFIF
810
GYQDSSSFYV
820
VMWKQTEQTY
830
WQATPFRAVA
840
EPGIQLKAVK
850
SKTGPGEHLR
860
NSLWHTGDTS
870
DQVRLLWKDS
880
RNVGWKDKVS
890
YRWFLQHRPQ
900
VGYIRVRFYE
910
GSELVADSGV
920
TIDTTMRGGR
930
LGVFCFSQEN
940
IIWSNLKYRC
950
NDTIPEDFQE
960
FQTQNFDRFD
N
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005604 |
basement membrane |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0031012 |
extracellular matrix |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0016529 |
sarcoplasmic reticulum |
| Cellular Component |
GO:1990341 |
thrombospondin complex |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0008083 |
growth factor activity |
| Molecular Function |
GO:0008201 |
heparin binding |
| Molecular Function |
GO:0005178 |
integrin binding |
| Biological Process |
GO:0048266 |
behavioral response to pain |
| Biological Process |
GO:0071603 |
endothelial cell-cell adhesion |
| Biological Process |
GO:0051451 |
myoblast migration |
| Biological Process |
GO:0016525 |
negative regulation of angiogenesis |
| Biological Process |
GO:0051781 |
positive regulation of cell division |
| Biological Process |
GO:0001938 |
positive regulation of endothelial cell proliferation |
| Biological Process |
GO:0090023 |
positive regulation of neutrophil chemotaxis |
| Biological Process |
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
| Biological Process |
GO:0034103 |
regulation of tissue remodeling |
| Biological Process |
GO:0034976 |
response to endoplasmic reticulum stress |
| Biological Process |
GO:0006986 |
response to unfolded protein |
| Biological Process |
GO:0048771 |
tissue remodeling |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.