Search Results
Overview
| Uniprot ID | P35527 |
|---|---|
| Protein Name | Keratin, type I cytoskeletal 9 |
| Gene Name | KRT9 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 170 | RLASYLDKVQALEEA |
| 184 | ANNDLENKIQDWYDK |
| 192 | IQDWYDKKGPAAIQK |
| 242 | TLDDFRIKFEMEQNL |
| 402 | EKSLEDTKNRYCGQL |
| 472 | FESSGAGKIGLGGRG |
Function
Structural component of intermediate filaments in suprabasal keratinocytes of palmoplantar epidermis. Forms heteropolymers with a type II keratin, assembling into keratin intermediate filament networks that maintain the mechanical integrity of the palmoplantar epidermis
Protein Sequence
10
MSCRQFSSSY
20
LSRSGGGGGG
30
GLGSGGSIRS
40
SYSRFSSSGG
50
GGGGGRFSSS
60
SGYGGGSSRV
70
CGRGGGGSFG
80
YSYGGGSGGG
90
FSASSLGGGF
100
GGGSRGFGGA
110
SGGGYSSSGG
120
FGGGFGGGSG
130
GGFGGGYGSG
140
FGGFGGFGGG
150
AGGGDGGILT
160
ANEKSTMQEL
170
NSRLASYLDK
180
VQALEEANND
190
LENKIQDWYD
200
KKGPAAIQKN
210
YSPYYNTIDD
220
LKDQIVDLTV
230
GNNKTLLDID
240
NTRMTLDDFR
250
IKFEMEQNLR
260
QGVDADINGL
270
RQVLDNLTME
280
KSDLEMQYET
290
LQEELMALKK
300
NHKEEMSQLT
310
GQNSGDVNVE
320
INVAPGKDLT
330
KTLNDMRQEY
340
EQLIAKNRKD
350
IENQYETQIT
360
QIEHEVSSSG
370
QEVQSSAKEV
380
TQLRHGVQEL
390
EIELQSQLSK
400
KAALEKSLED
410
TKNRYCGQLQ
420
MIQEQISNLE
430
AQITDVRQEI
440
ECQNQEYSLL
450
LSIKMRLEKE
460
IETYHNLLEG
470
GQEDFESSGA
480
GKIGLGGRGG
490
SGGSYGRGSR
500
GGSGGSYGGG
510
GSGGGYGGGS
520
GSRGGSGGSY
530
GGGSGSGGGS
540
GGGYGGGSGG
550
GHSGGSGGGH
560
SGGSGGNYGG
570
GSGSGGGSGG
580
GYGGGSGSRG
590
GSGGSHGGGS
600
GFGGESGGSY
610
GGGEEASGSG
620
GGYGGGSGKS
SHS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0045095 | keratin filament |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Molecular Function | GO:0030280 | structural constituent of skin epidermis |
| Biological Process | GO:0008544 | epidermis development |
| Biological Process | GO:0030855 | epithelial cell differentiation |
| Biological Process | GO:0045109 | intermediate filament organization |
| Biological Process | GO:0002009 | morphogenesis of an epithelium |
| Biological Process | GO:0043588 | skin development |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.