Search Results

Overview

Uniprot IDP35556
Protein NameFibrillin-2
Gene NameFBN2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
2815 NLSHLGSKEHILELR

Function

Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively

Protein Sequence

10 MGRRRRLCLQ 20 LYFLWLGCVV 30 LWAQGTAGQP 40 QPPPPKPPRP 50 QPPPQQVRSA 60 TAGSEGGFLA 70 PEYREEGAAV 80 ASRVRRRGQQ 90 DVLRGPNVCG 100 SRFHSYCCPG 110 WKTLPGGNQC 120 IVPICRNSCG 130 DGFCSRPNMC 140 TCSSGQISST 150 CGSKSIQQCS 160 VRCMNGGTCA 170 DDHCQCQKGY 180 IGTYCGQPVC 190 ENGCQNGGRC 200 IGPNRCACVY 210 GFTGPQCERD 220 YRTGPCFTQV 230 NNQMCQGQLT 240 GIVCTKTLCC 250 ATIGRAWGHP 260 CEMCPAQPQP 270 CRRGFIPNIR 280 TGACQDVDEC 290 QAIPGICQGG 300 NCINTVGSFE 310 CRCPAGHKQS 320 ETTQKCEDID 330 ECSIIPGICE 340 TGECSNTVGS 350 YFCVCPRGYV 360 TSTDGSRCID 370 QRTGMCFSGL 380 VNGRCAQELP 390 GRMTKMQCCC 400 EPGRCWGIGT 410 IPEACPVRGS 420 EEYRRLCMDG 430 LPMGGIPGSA 440 GSRPGGTGGN 450 GFAPSGNGNG 460 YGPGGTGFIP 470 IPGGNGFSPG 480 VGGAGVGAGG 490 QGPIITGLTI 500 LNQTIDICKH 510 HANLCLNGRC 520 IPTVSSYRCE 530 CNMGYKQDAN 540 GDCIDVDECT 550 SNPCTNGDCV 560 NTPGSYYCKC 570 HAGFQRTPTK 580 QACIDIDECI 590 QNGVLCKNGR 600 CVNTDGSFQC 610 ICNAGFELTT 620 DGKNCVDHDE 630 CTTTNMCLNG 640 MCINEDGSFK 650 CICKPGFVLA 660 PNGRYCTDVD 670 ECQTPGICMN 680 GHCINSEGSF 690 RCDCPPGLAV 700 GMDGRVCVDT 710 HMRSTCYGGI 720 KKGVCVRPFP 730 GAVTKSECCC 740 ANPDYGFGEP 750 CQPCPAKNSA 760 EFHGLCSSGV 770 GITVDGRDIN 780 ECALDPDICA 790 NGICENLRGS 800 YRCNCNSGYE 810 PDASGRNCID 820 IDECLVNRLL 830 CDNGLCRNTP 840 GSYSCTCPPG 850 YVFRTETETC 860 EDINECESNP 870 CVNGACRNNL 880 GSFNCECSPG 890 SKLSSTGLIC 900 IDSLKGTCWL 910 NIQDSRCEVN 920 INGATLKSEC 930 CATLGAAWGS 940 PCERCELDTA 950 CPRGLARIKG 960 VTCEDVNECE 970 VFPGVCPNGR 980 CVNSKGSFHC 990 ECPEGLTLDG 1000 TGRVCLDIRM 1010 EQCYLKWDED 1020 ECIHPVPGKF 1030 RMDACCCAVG 1040 AAWGTECEEC 1050 PKPGTKEYET 1060 LCPRGAGFAN 1070 RGDVLTGRPF 1080 YKDINECKAF 1090 PGMCTYGKCR 1100 NTIGSFKCRC 1110 NSGFALDMEE 1120 RNCTDIDECR 1130 ISPDLCGSGI 1140 CVNTPGSFEC 1150 ECFEGYESGF 1160 MMMKNCMDID 1170 ECERNPLLCR 1180 GGTCVNTEGS 1190 FQCDCPLGHE 1200 LSPSREDCVD 1210 INECSLSDNL 1220 CRNGKCVNMI 1230 GTYQCSCNPG 1240 YQATPDRQGC 1250 TDIDECMIMN 1260 GGCDTQCTNS 1270 EGSYECSCSE 1280 GYALMPDGRS 1290 CADIDECENN 1300 PDICDGGQCT 1310 NIPGEYRCLC 1320 YDGFMASMDM 1330 KTCIDVNECD 1340 LNSNICMFGE 1350 CENTKGSFIC 1360 HCQLGYSVKK 1370 GTTGCTDVDE 1380 CEIGAHNCDM 1390 HASCLNIPGS 1400 FKCSCREGWI 1410 GNGIKCIDLD 1420 ECSNGTHQCS 1430 INAQCVNTPG 1440 SYRCACSEGF 1450 TGDGFTCSDV 1460 DECAENINLC 1470 ENGQCLNVPG 1480 AYRCECEMGF 1490 TPASDSRSCQ 1500 DIDECSFQNI 1510 CVFGTCNNLP 1520 GMFHCICDDG 1530 YELDRTGGNC 1540 TDIDECADPI 1550 NCVNGLCVNT 1560 PGRYECNCPP 1570 DFQLNPTGVG 1580 CVDNRVGNCY 1590 LKFGPRGDGS 1600 LSCNTEIGVG 1610 VSRSSCCCSL 1620 GKAWGNPCET 1630 CPPVNSTEYY 1640 TLCPGGEGFR 1650 PNPITIILED 1660 IDECQELPGL 1670 CQGGNCINTF 1680 GSFQCECPQG 1690 YYLSEDTRIC 1700 EDIDECFAHP 1710 GVCGPGTCYN 1720 TLGNYTCICP 1730 PEYMQVNGGH 1740 NCMDMRKSFC 1750 YRSYNGTTCE 1760 NELPFNVTKR 1770 MCCCTYNVGK 1780 AWNKPCEPCP 1790 TPGTADFKTI 1800 CGNIPGFTFD 1810 IHTGKAVDID 1820 ECKEIPGICA 1830 NGVCINQIGS 1840 FRCECPTGFS 1850 YNDLLLVCED 1860 IDECSNGDNL 1870 CQRNADCINS 1880 PGSYRCECAA 1890 GFKLSPNGAC 1900 VDRNECLEIP 1910 NVCSHGLCVD 1920 LQGSYQCICH 1930 NGFKASQDQT 1940 MCMDVDECER 1950 HPCGNGTCKN 1960 TVGSYNCLCY 1970 PGFELTHNND 1980 CLDIDECSSF 1990 FGQVCRNGRC 2000 FNEIGSFKCL 2010 CNEGYELTPD 2020 GKNCIDTNEC 2030 VALPGSCSPG 2040 TCQNLEGSFR 2050 CICPPGYEVK 2060 SENCIDINEC 2070 DEDPNICLFG 2080 SCTNTPGGFQ 2090 CLCPPGFVLS 2100 DNGRRCFDTR 2110 QSFCFTNFEN 2120 GKCSVPKAFN 2130 TTKAKCCCSK 2140 MPGEGWGDPC 2150 ELCPKDDEVA 2160 FQDLCPYGHG 2170 TVPSLHDTRE 2180 DVNECLESPG 2190 ICSNGQCINT 2200 DGSFRCECPM 2210 GYNLDYTGVR 2220 CVDTDECSIG 2230 NPCGNGTCTN 2240 VIGSFECNCN 2250 EGFEPGPMMN 2260 CEDINECAQN 2270 PLLCAFRCMN 2280 TFGSYECTCP 2290 IGYALREDQK 2300 MCKDLDECAE 2310 GLHDCESRGM 2320 MCKNLIGTFM 2330 CICPPGMARR 2340 PDGEGCVDEN 2350 ECRTKPGICE 2360 NGRCVNIIGS 2370 YRCECNEGFQ 2380 SSSSGTECLD 2390 NRQGLCFAEV 2400 LQTICQMASS 2410 SRNLVTKSEC 2420 CCDGGRGWGH 2430 QCELCPLPGT 2440 AQYKKICPHG 2450 PGYTTDGRDI 2460 DECKVMPNLC 2470 TNGQCINTMG 2480 SFRCFCKVGY 2490 TTDISGTSCI 2500 DLDECSQSPK 2510 PCNYICKNTE 2520 GSYQCSCPRG 2530 YVLQEDGKTC 2540 KDLDECQTKQ 2550 HNCQFLCVNT 2560 LGGFTCKCPP 2570 GFTQHHTACI 2580 DNNECGSQPS 2590 LCGAKGICQN 2600 TPGSFSCECQ 2610 RGFSLDATGL 2620 NCEDVDECDG 2630 NHRCQHGCQN 2640 ILGGYRCGCP 2650 QGYIQHYQWN 2660 QCVDENECSN 2670 PNACGSASCY 2680 NTLGSYKCAC 2690 PSGFSFDQFS 2700 SACHDVNECS 2710 SSKNPCNYGC 2720 SNTEGGYLCG 2730 CPPGYYRVGQ 2740 GHCVSGMGFN 2750 KGQYLSLDTE 2760 VDEENALSPE 2770 ACYECKINGY 2780 SKKDSRQKRS 2790 IHEPDPTAVE 2800 QISLESVDMD 2810 SPVNMKFNLS 2820 HLGSKEHILE 2830 LRPAIQPLNN 2840 HIRYVISQGN 2850 DDSVFRIHQR 2860 NGLSYLHTAK 2870 KKLMPGTYTL 2880 EITSIPLYKK 2890 KELKKLEESN 2900 EDDYLLGELG 2910 EALRMRLQIQ LY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0001527 microfibril
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0030023 extracellular matrix constituent conferring elasticity
Molecular Function GO:0005201 extracellular matrix structural constituent
Molecular Function GO:0005179 hormone activity
Biological Process GO:0060346 bone trabecula formation
Biological Process GO:0043010 camera-type eye development
Biological Process GO:0048048 embryonic eye morphogenesis
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0030501 positive regulation of bone mineralization
Biological Process GO:0045669 positive regulation of osteoblast differentiation

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.