Overview
| Uniprot ID | P35565 |
|---|
| Protein Name | Calnexin |
|---|
| Gene Name | Canx |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 119 |
ETKLPGDKGLVLMSR |
| 171 |
AYVKLLSKTSELNLD |
| 211 |
IFRHKNPKTGVYEEK |
| 228 |
KRPDADLKTYFTDKK |
| 234 |
LKTYFTDKKTHLYTL |
| 381 |
MIDNPNYKGKWKPPM |
| 459 |
ANDGWGLKKAADGAA |
| 88 |
LSGWILSKAKKDDTD |
| 90 |
GWILSKAKKDDTDDE |
Function
Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse
Protein Sequence
10
MEGKWLLCLL
20
LVLGTAAIQA
30
HDGHDDDMID
40
IEDDLDDVIE
50
EVEDSKSKSD
60
TSTPPSPKVT
70
YKAPVPTGEV
80
YFADSFDRGS
90
LSGWILSKAK
100
KDDTDDEIAK
110
YDGKWEVDEM
120
KETKLPGDKG
130
LVLMSRAKHH
140
AISAKLNKPF
150
LFDTKPLIVQ
160
YEVNFQNGIE
170
CGGAYVKLLS
180
KTSELNLDQF
190
HDKTPYTIMF
200
GPDKCGEDYK
210
LHFIFRHKNP
220
KTGVYEEKHA
230
KRPDADLKTY
240
FTDKKTHLYT
250
LILNPDNSFE
260
ILVDQSVVNS
270
GNLLNDMTPP
280
VNPSREIEDP
290
EDRKPEDWDE
300
RPKIADPDAV
310
KPDDWDEDAP
320
SKIPDEEATK
330
PEGWLDDEPE
340
YIPDPDAEKP
350
EDWDEDMDGE
360
WEAPQIANPK
370
CESAPGCGVW
380
QRPMIDNPNY
390
KGKWKPPMID
400
NPNYQGIWKP
410
RKIPNPDFFE
420
DLEPFRMTPF
430
SAIGLELWSM
440
TSDIFFDNFI
450
ISGDRRVVDD
460
WANDGWGLKK
470
AADGAAEPGV
480
VGQMLEAAEE
490
RPWLWVVYIL
500
TVALPVFLVI
510
LFCCSGKKQS
520
NAMEYKKTDA
530
PQPDVKDEEG
540
KEEEKNKGDE
550
EEEEEKLEEK
560
QKSDAEEDGG
570
TGSQDEEDSK
580
PKAEEDEILN
590
RSPRNRKPRR
E
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030424 |
axon |
| Cellular Component |
GO:0032839 |
dendrite cytoplasm |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0030246 |
carbohydrate binding |
| Molecular Function |
GO:0035255 |
ionotropic glutamate receptor binding |
| Molecular Function |
GO:0051082 |
unfolded protein binding |
| Biological Process |
GO:0072583 |
clathrin-dependent endocytosis |
| Biological Process |
GO:0036503 |
ERAD pathway |
| Biological Process |
GO:0006457 |
protein folding |
| Biological Process |
GO:0048488 |
synaptic vesicle endocytosis |
| Cellular Component |
GO:0043197 |
dendritic spine |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0044322 |
endoplasmic reticulum quality control compartment |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0033162 |
melanosome membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0044233 |
mitochondria-associated endoplasmic reticulum membrane contact site |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Cellular Component |
GO:0031965 |
nuclear membrane |
| Cellular Component |
GO:0045211 |
postsynaptic membrane |
| Cellular Component |
GO:0048787 |
presynaptic active zone membrane |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Cellular Component |
GO:0005840 |
ribosome |
| Cellular Component |
GO:0005790 |
smooth endoplasmic reticulum |
| Molecular Function |
GO:0034185 |
apolipoprotein binding |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.