Search Results

Overview

Uniprot IDP35573
Protein NameGlycogen debranching enzyme
Gene NameAGL
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1077 LNEITKEKEQCCVSL
1303 WLLELSKKNIFPYHE
1314 PYHEVTVKRHGKAIK
1321 KRHGKAIKVSYDEWN
1330 SYDEWNRKIQDNFEK
1351 DPSDLNEKHPNLVHK
1406 KALEIAEKKLLGPLG
1407 ALEIAEKKLLGPLGM
1462 IGYFLRAKLYFSRLM
1476 MGPETTAKTIVLVKN
1482 AKTIVLVKNVLSRHY
17 LLLNEMEKLEKTLFR
191 DFSRPNRKYTWNDVG
265 SCDVAEGKYKEKGIP
326 QENRRVTKSDPNQHL
376 ECCNWFHKRMEELNS
385 MEELNSEKHRLINYH
422 KLGPVTRKHPLVTRY
511 YLWAHMKKYTEITAT
816 HIQLNESKIVKQAGV
819 LNESKIVKQAGVATK

Function

Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation

Protein Sequence

10 MGHSKQIRIL 20 LLNEMEKLEK 30 TLFRLEQGYE 40 LQFRLGPTLQ 50 GKAVTVYTNY 60 PFPGETFNRE 70 KFRSLDWENP 80 TEREDDSDKY 90 CKLNLQQSGS 100 FQYYFLQGNE 110 KSGGGYIVVD 120 PILRVGADNH 130 VLPLDCVTLQ 140 TFLAKCLGPF 150 DEWESRLRVA 160 KESGYNMIHF 170 TPLQTLGLSR 180 SCYSLANQLE 190 LNPDFSRPNR 200 KYTWNDVGQL 210 VEKLKKEWNV 220 ICITDVVYNH 230 TAANSKWIQE 240 HPECAYNLVN 250 SPHLKPAWVL 260 DRALWRFSCD 270 VAEGKYKEKG 280 IPALIENDHH 290 MNSIRKIIWE 300 DIFPKLKLWE 310 FFQVDVNKAV 320 EQFRRLLTQE 330 NRRVTKSDPN 340 QHLTIIQDPE 350 YRRFGCTVDM 360 NIALTTFIPH 370 DKGPAAIEEC 380 CNWFHKRMEE 390 LNSEKHRLIN 400 YHQEQAVNCL 410 LGNVFYERLA 420 GHGPKLGPVT 430 RKHPLVTRYF 440 TFPFEEIDFS 450 MEESMIHLPN 460 KACFLMAHNG 470 WVMGDDPLRN 480 FAEPGSEVYL 490 RRELICWGDS 500 VKLRYGNKPE 510 DCPYLWAHMK 520 KYTEITATYF 530 QGVRLDNCHS 540 TPLHVAEYML 550 DAARNLQPNL 560 YVVAELFTGS 570 EDLDNVFVTR 580 LGISSLIREA 590 MSAYNSHEEG 600 RLVYRYGGEP 610 VGSFVQPCLR 620 PLMPAIAHAL 630 FMDITHDNEC 640 PIVHRSAYDA 650 LPSTTIVSMA 660 CCASGSTRGY 670 DELVPHQISV 680 VSEERFYTKW 690 NPEALPSNTG 700 EVNFQSGIIA 710 ARCAISKLHQ 720 ELGAKGFIQV 730 YVDQVDEDIV 740 AVTRHSPSIH 750 QSVVAVSRTA 760 FRNPKTSFYS 770 KEVPQMCIPG 780 KIEEVVLEAR 790 TIERNTKPYR 800 KDENSINGTP 810 DITVEIREHI 820 QLNESKIVKQ 830 AGVATKGPNE 840 YIQEIEFENL 850 SPGSVIIFRV 860 SLDPHAQVAV 870 GILRNHLTQF 880 SPHFKSGSLA 890 VDNADPILKI 900 PFASLASRLT 910 LAELNQILYR 920 CESEEKEDGG 930 GCYDIPNWSA 940 LKYAGLQGLM 950 SVLAEIRPKN 960 DLGHPFCNNL 970 RSGDWMIDYV 980 SNRLISRSGT 990 IAEVGKWLQA 1000 MFFYLKQIPR 1010 YLIPCYFDAI 1020 LIGAYTTLLD 1030 TAWKQMSSFV 1040 QNGSTFVKHL 1050 SLGSVQLCGV 1060 GKFPSLPILS 1070 PALMDVPYRL 1080 NEITKEKEQC 1090 CVSLAAGLPH 1100 FSSGIFRCWG 1110 RDTFIALRGI 1120 LLITGRYVEA 1130 RNIILAFAGT 1140 LRHGLIPNLL 1150 GEGIYARYNC 1160 RDAVWWWLQC 1170 IQDYCKMVPN 1180 GLDILKCPVS 1190 RMYPTDDSAP 1200 LPAGTLDQPL 1210 FEVIQEAMQK 1220 HMQGIQFRER 1230 NAGPQIDRNM 1240 KDEGFNITAG 1250 VDEETGFVYG 1260 GNRFNCGTWM 1270 DKMGESDRAR 1280 NRGIPATPRD 1290 GSAVEIVGLS 1300 KSAVRWLLEL 1310 SKKNIFPYHE 1320 VTVKRHGKAI 1330 KVSYDEWNRK 1340 IQDNFEKLFH 1350 VSEDPSDLNE 1360 KHPNLVHKRG 1370 IYKDSYGASS 1380 PWCDYQLRPN 1390 FTIAMVVAPE 1400 LFTTEKAWKA 1410 LEIAEKKLLG 1420 PLGMKTLDPD 1430 DMVYCGIYDN 1440 ALDNDNYNLA 1450 KGFNYHQGPE 1460 WLWPIGYFLR 1470 AKLYFSRLMG 1480 PETTAKTIVL 1490 VKNVLSRHYV 1500 HLERSPWKGL 1510 PELTNENAQY 1520 CPFSCETQAW 1530 SIATILETLY DL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0016234 inclusion body
Cellular Component GO:0043033 isoamylase complex
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0016529 sarcoplasmic reticulum
Cellular Component GO:0034774 secretory granule lumen
Molecular Function GO:0004134 4-alpha-glucanotransferase activity
Molecular Function GO:0004135 amylo-alpha-1,6-glucosidase activity
Molecular Function GO:0030247 polysaccharide binding
Molecular Function GO:0031593 polyubiquitin modification-dependent protein binding
Biological Process GO:0005978 glycogen biosynthetic process
Biological Process GO:0005980 glycogen catabolic process
Biological Process GO:0051384 response to glucocorticoid
Biological Process GO:0007584 response to nutrient

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.