Search Results

Overview

Uniprot IDP35580
Protein NameMyosin-10
Gene NameMYH10
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1256 ESEHKRKKLDAQVQE
1284 ELAEKASKLQNELDN
1411 LSQRLEEKALAYDKL
1417 EKALAYDKLEKTKNR
1610 AELEDERKQRALAVA
1782 AERSAAQKSDNARQQ
206 ASSHKGRKDHNIPGE
442 WLVHRINKALDRTKR
547 WFPKATDKTFVEKLV
767 LYRIGQSKIFFRAGV

Function

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9

Protein Sequence

10 MAQRTGLEDP 20 ERYLFVDRAV 30 IYNPATQADW 40 TAKKLVWIPS 50 ERHGFEAASI 60 KEERGDEVMV 70 ELAENGKKAM 80 VNKDDIQKMN 90 PPKFSKVEDM 100 AELTCLNEAS 110 VLHNLKDRYY 120 SGLIYTYSGL 130 FCVVINPYKN 140 LPIYSENIIE 150 MYRGKKRHEM 160 PPHIYAISES 170 AYRCMLQDRE 180 DQSILCTGES 190 GAGKTENTKK 200 VIQYLAHVAS 210 SHKGRKDHNI 220 PGELERQLLQ 230 ANPILESFGN 240 AKTVKNDNSS 250 RFGKFIRINF 260 DVTGYIVGAN 270 IETYLLEKSR 280 AVRQAKDERT 290 FHIFYQLLSG 300 AGEHLKSDLL 310 LEGFNNYRFL 320 SNGYIPIPGQ 330 QDKDNFQETM 340 EAMHIMGFSH 350 EEILSMLKVV 360 SSVLQFGNIS 370 FKKERNTDQA 380 SMPENTVAQK 390 LCHLLGMNVM 400 EFTRAILTPR 410 IKVGRDYVQK 420 AQTKEQADFA 430 VEALAKATYE 440 RLFRWLVHRI 450 NKALDRTKRQ 460 GASFIGILDI 470 AGFEIFELNS 480 FEQLCINYTN 490 EKLQQLFNHT 500 MFILEQEEYQ 510 REGIEWNFID 520 FGLDLQPCID 530 LIERPANPPG 540 VLALLDEECW 550 FPKATDKTFV 560 EKLVQEQGSH 570 SKFQKPRQLK 580 DKADFCIIHY 590 AGKVDYKADE 600 WLMKNMDPLN 610 DNVATLLHQS 620 SDRFVAELWK 630 DVDRIVGLDQ 640 VTGMTETAFG 650 SAYKTKKGMF 660 RTVGQLYKES 670 LTKLMATLRN 680 TNPNFVRCII 690 PNHEKRAGKL 700 DPHLVLDQLR 710 CNGVLEGIRI 720 CRQGFPNRIV 730 FQEFRQRYEI 740 LTPNAIPKGF 750 MDGKQACERM 760 IRALELDPNL 770 YRIGQSKIFF 780 RAGVLAHLEE 790 ERDLKITDII 800 IFFQAVCRGY 810 LARKAFAKKQ 820 QQLSALKVLQ 830 RNCAAYLKLR 840 HWQWWRVFTK 850 VKPLLQVTRQ 860 EEELQAKDEE 870 LLKVKEKQTK 880 VEGELEEMER 890 KHQQLLEEKN 900 ILAEQLQAET 910 ELFAEAEEMR 920 ARLAAKKQEL 930 EEILHDLESR 940 VEEEEERNQI 950 LQNEKKKMQA 960 HIQDLEEQLD 970 EEEGARQKLQ 980 LEKVTAEAKI 990 KKMEEEILLL 1000 EDQNSKFIKE 1010 KKLMEDRIAE 1020 CSSQLAEEEE 1030 KAKNLAKIRN 1040 KQEVMISDLE 1050 ERLKKEEKTR 1060 QELEKAKRKL 1070 DGETTDLQDQ 1080 IAELQAQIDE 1090 LKLQLAKKEE 1100 ELQGALARGD 1110 DETLHKNNAL 1120 KVVRELQAQI 1130 AELQEDFESE 1140 KASRNKAEKQ 1150 KRDLSEELEA 1160 LKTELEDTLD 1170 TTAAQQELRT 1180 KREQEVAELK 1190 KALEEETKNH 1200 EAQIQDMRQR 1210 HATALEELSE 1220 QLEQAKRFKA 1230 NLEKNKQGLE 1240 TDNKELACEV 1250 KVLQQVKAES 1260 EHKRKKLDAQ 1270 VQELHAKVSE 1280 GDRLRVELAE 1290 KASKLQNELD 1300 NVSTLLEEAE 1310 KKGIKFAKDA 1320 ASLESQLQDT 1330 QELLQEETRQ 1340 KLNLSSRIRQ 1350 LEEEKNSLQE 1360 QQEEEEEARK 1370 NLEKQVLALQ 1380 SQLADTKKKV 1390 DDDLGTIESL 1400 EEAKKKLLKD 1410 AEALSQRLEE 1420 KALAYDKLEK 1430 TKNRLQQELD 1440 DLTVDLDHQR 1450 QVASNLEKKQ 1460 KKFDQLLAEE 1470 KSISARYAEE 1480 RDRAEAEARE 1490 KETKALSLAR 1500 ALEEALEAKE 1510 EFERQNKQLR 1520 ADMEDLMSSK 1530 DDVGKNVHEL 1540 EKSKRALEQQ 1550 VEEMRTQLEE 1560 LEDELQATED 1570 AKLRLEVNMQ 1580 AMKAQFERDL 1590 QTRDEQNEEK 1600 KRLLIKQVRE 1610 LEAELEDERK 1620 QRALAVASKK 1630 KMEIDLKDLE 1640 AQIEAANKAR 1650 DEVIKQLRKL 1660 QAQMKDYQRE 1670 LEEARASRDE 1680 IFAQSKESEK 1690 KLKSLEAEIL 1700 QLQEELASSE 1710 RARRHAEQER 1720 DELADEITNS 1730 ASGKSALLDE 1740 KRRLEARIAQ 1750 LEEELEEEQS 1760 NMELLNDRFR 1770 KTTLQVDTLN 1780 AELAAERSAA 1790 QKSDNARQQL 1800 ERQNKELKAK 1810 LQELEGAVKS 1820 KFKATISALE 1830 AKIGQLEEQL 1840 EQEAKERAAA 1850 NKLVRRTEKK 1860 LKEIFMQVED 1870 ERRHADQYKE 1880 QMEKANARMK 1890 QLKRQLEEAE 1900 EEATRANASR 1910 RKLQRELDDA 1920 TEANEGLSRE 1930 VSTLKNRLRR 1940 GGPISFSSSR 1950 SGRRQLHLEG 1960 ASLELSDDDT 1970 ESKTSDVNET QPPQSE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0042641 actomyosin
Cellular Component GO:0005903 brush border
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0009986 cell surface
Cellular Component GO:0032154 cleavage furrow
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0009898 cytoplasmic side of plasma membrane
Cellular Component GO:0005829 cytosol
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0030426 growth cone
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0030496 midbody
Cellular Component GO:0016459 myosin complex
Cellular Component GO:0032982 myosin filament
Cellular Component GO:0016460 myosin II complex
Cellular Component GO:0097513 myosin II filament
Cellular Component GO:0031594 neuromuscular junction
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005634 nucleus
Cellular Component GO:0098871 postsynaptic actin cytoskeleton
Cellular Component GO:0005819 spindle
Cellular Component GO:0001725 stress fiber
Molecular Function GO:0003779 actin binding
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0043531 ADP binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0000146 microfilament motor activity
Molecular Function GO:0048027 mRNA 5'-UTR binding
Molecular Function GO:0035613 RNA stem-loop binding
Molecular Function GO:0001618 virus receptor activity
Biological Process GO:0030048 actin filament-based movement
Biological Process GO:0031032 actomyosin structure organization
Biological Process GO:0007155 cell adhesion
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0050714 positive regulation of protein secretion
Biological Process GO:0098974 postsynaptic actin cytoskeleton organization
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0046718 symbiont entry into host cell

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.