Search Results
Overview
| Uniprot ID | P35606 |
|---|---|
| Protein Name | Coatomer subunit beta' |
| Gene Name | COPB2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 346 | ERLPLAVKDMGSCEI |
Function
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors
Protein Sequence
10
MPLRLDIKRK
20
LTARSDRVKS
30
VDLHPTEPWM
40
LASLYNGSVC
50
VWNHETQTLV
60
KTFEVCDLPV
70
RAAKFVARKN
80
WVVTGADDMQ
90
IRVFNYNTLE
100
RVHMFEAHSD
110
YIRCIAVHPT
120
QPFILTSSDD
130
MLIKLWDWDK
140
KWSCSQVFEG
150
HTHYVMQIVI
160
NPKDNNQFAS
170
ASLDRTIKVW
180
QLGSSSPNFT
190
LEGHEKGVNC
200
IDYYSGGDKP
210
YLISGADDRL
220
VKIWDYQNKT
230
CVQTLEGHAQ
240
NVSCASFHPE
250
LPIIITGSED
260
GTVRIWHSST
270
YRLESTLNYG
280
MERVWCVASL
290
RGSNNVALGY
300
DEGSIIVKLG
310
REEPAMSMDA
320
NGKIIWAKHS
330
EVQQANLKAM
340
GDAEIKDGER
350
LPLAVKDMGS
360
CEIYPQTIQH
370
NPNGRFVVVC
380
GDGEYIIYTA
390
MALRNKSFGS
400
AQEFAWAHDS
410
SEYAIRESNS
420
IVKIFKNFKE
430
KKSFKPDFGA
440
ESIYGGFLLG
450
VRSVNGLAFY
460
DWDNTELIRR
470
IEIQPKHIFW
480
SDSGELVCIA
490
TEESFFILKY
500
LSEKVLAAQE
510
THEGVTEDGI
520
EDAFEVLGEI
530
QEIVKTGLWV
540
GDCFIYTSSV
550
NRLNYYVGGE
560
IVTIAHLDRT
570
MYLLGYIPKD
580
NRLYLGDKEL
590
NIISYSLLVS
600
VLEYQTAVMR
610
RDFSMADKVL
620
PTIPKEQRTR
630
VAHFLEKQGF
640
KQQALTVSTD
650
PEHRFELALQ
660
LGELKIAYQL
670
AVEAESEQKW
680
KQLAELAISK
690
CQFGLAQECL
700
HHAQDYGGLL
710
LLATASGNAN
720
MVNKLAEGAE
730
RDGKNNVAFM
740
SYFLQGKVDA
750
CLELLIRTGR
760
LPEAAFLART
770
YLPSQVSRVV
780
KLWRENLSKV
790
NQKAAESLAD
800
PTEYENLFPG
810
LKEAFVVEEW
820
VKETHADLWP
830
AKQYPLVTPN
840
EERNVMEEGK
850
DFQPSRSTAQ
860
QELDGKPASP
870
TPVIVASHTA
880
NKEEKSLLEL
890
EVDLDNLELE
900
DIDTTDINLD
EDILDD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Cellular Component | GO:0030126 | COPI vesicle coat |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0030133 | transport vesicle |
| Molecular Function | GO:0005198 | structural molecule activity |
| Biological Process | GO:0006891 | intra-Golgi vesicle-mediated transport |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
Reference
PMID: N/A