Search Results
Overview
| Uniprot ID | P35612 |
|---|---|
| Protein Name | Beta-adducin |
| Gene Name | ADD2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 163 | YVTLRVSKEQDHFLI |
| 276 | ADRINLQKCLGPTCK |
| 527 | LASVIAEKSRSPSTE |
Function
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit
Protein Sequence
10
MSEETVPEAA
20
SPPPPQGQPY
30
FDRFSEDDPE
40
YMRLRNRAAD
50
LRQDFNLMEQ
60
KKRVTMILQS
70
PSFREELEGL
80
IQEQMKKGNN
90
SSNIWALRQI
100
ADFMASTSHA
110
VFPTSSMNVS
120
MMTPINDLHT
130
ADSLNLAKGE
140
RLMRCKISSV
150
YRLLDLYGWA
160
QLSDTYVTLR
170
VSKEQDHFLI
180
SPKGVSCSEV
190
TASSLIKVNI
200
LGEVVEKGSS
210
CFPVDTTGFC
220
LHSAIYAARP
230
DVRCIIHLHT
240
PATAAVSAMK
250
WGLLPVSHNA
260
LLVGDMAYYD
270
FNGEMEQEAD
280
RINLQKCLGP
290
TCKILVLRNH
300
GVVALGDTVE
310
EAFYKIFHLQ
320
AACEIQVSAL
330
SSAGGVENLI
340
LLEQEKHRPH
350
EVGSVQWAGS
360
TFGPMQKSRL
370
GEHEFEALMR
380
MLDNLGYRTG
390
YTYRHPFVQE
400
KTKHKSEVEI
410
PATVTAFVFE
420
EDGAPVPALR
430
QHAQKQQKEK
440
TRWLNTPNTY
450
LRVNVADEVQ
460
RSMGSPRPKT
470
TWMKADEVEK
480
SSSGMPIRIE
490
NPNQFVPLYT
500
DPQEVLEMRN
510
KIREQNRQDV
520
KSAGPQSQLL
530
ASVIAEKSRS
540
PSTESQLMSK
550
GDEDTKDDSE
560
ETVPNPFSQL
570
TDQELEEYKK
580
EVERKKLELD
590
GEKETAPEEP
600
GSPAKSAPAS
610
PVQSPAKEAE
620
TKSPLVSPSK
630
SLEEGTKKTE
640
TSKAATTEPE
650
TTQPEGVVVN
660
GREEEQTAEE
670
ILSKGLSQMT
680
TSADTDVDTS
690
KDKTESVTSG
700
PMSPEGSPSK
710
SPSKKKKKFR
720
TPSFLKKSKK
KEKVES
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0008290 | F-actin capping protein complex |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0044853 | plasma membrane raft |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0014731 | spectrin-associated cytoskeleton |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0008093 | cytoskeletal anchor activity |
| Molecular Function | GO:0046983 | protein dimerization activity |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0030507 | spectrin binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0051017 | actin filament bundle assembly |
| Biological Process | GO:0051016 | barbed-end actin filament capping |
| Biological Process | GO:0050900 | leukocyte migration |
| Biological Process | GO:0050901 | leukocyte tethering or rolling |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0030833 | regulation of actin filament polymerization |
| Biological Process | GO:0007416 | synapse assembly |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.