Search Results
Overview
| Uniprot ID | P35613 |
|---|---|
| Protein Name | Basigin |
| Gene Name | BSG |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 179 | LKGGVVLKEDALPGQ |
| 187 | EDALPGQKTEFKVDS |
| 227 | PPRVKAVKSSEHINE |
Function
Essential for normal retinal maturation and development (By similarity). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed:21620857)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0002080 | acrosomal membrane |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0001917 | photoreceptor inner segment |
| Cellular Component | GO:0001750 | photoreceptor outer segment |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0042383 | sarcolemma |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0098632 | cell-cell adhesion mediator activity |
| Molecular Function | GO:0005537 | D-mannose binding |
| Molecular Function | GO:0140597 | protein carrier chaperone |
| Molecular Function | GO:0038023 | signaling receptor activity |
| Molecular Function | GO:0001618 | virus receptor activity |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0007411 | axon guidance |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0046697 | decidualization |
| Biological Process | GO:0070593 | dendrite self-avoidance |
| Biological Process | GO:0007566 | embryo implantation |
| Biological Process | GO:0061154 | endothelial tube morphogenesis |
| Biological Process | GO:0007156 | homophilic cell-cell adhesion |
| Biological Process | GO:0003407 | neural retina development |
| Biological Process | GO:1990138 | neuron projection extension |
| Biological Process | GO:0030593 | neutrophil chemotaxis |
| Biological Process | GO:0042475 | odontogenesis of dentin-containing tooth |
| Biological Process | GO:0045494 | photoreceptor cell maintenance |
| Biological Process | GO:0010595 | positive regulation of endothelial cell migration |
| Biological Process | GO:0032755 | positive regulation of interleukin-6 production |
| Biological Process | GO:1904466 | positive regulation of matrix metallopeptidase secretion |
| Biological Process | GO:0010575 | positive regulation of vascular endothelial growth factor production |
| Biological Process | GO:0046598 | positive regulation of viral entry into host cell |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0051591 | response to cAMP |
| Biological Process | GO:0046689 | response to mercury ion |
| Biological Process | GO:0043434 | response to peptide hormone |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.