Search Results

Overview

Uniprot IDP35658
Protein NameNuclear pore complex protein Nup214
Gene NameNUP214
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1037 PHAAPFAKSHLVHGS
1076 MLATKTVKHGAPSPS
1309 ALSTTSSKLETPPSK
1347 GQADDSTKPTNKASS
1351 DSTKPTNKASSTSLT
665 PVPSMVQKSPRITPP
682 KPGSPQAKSLQPAVA
691 LQPAVAEKQGHQWKD

Function

Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440)

Protein Sequence

10 MGDEMDAMIP 20 EREMKDFQFR 30 ALKKVRIFDS 40 PEELPKERSS 50 LLAVSNKYGL 60 VFAGGASGLQ 70 IFPTKNLLIQ 80 NKPGDDPNKI 90 VDKVQGLLVP 100 MKFPIHHLAL 110 SCDNLTLSAC 120 MMSSEYGSII 130 AFFDVRTFSN 140 EAKQQKRPFA 150 YHKLLKDAGG 160 MVIDMKWNPT 170 VPSMVAVCLA 180 DGSIAVLQVT 190 ETVKVCATLP 200 STVAVTSVCW 210 SPKGKQLAVG 220 KQNGTVVQYL 230 PTLQEKKVIP 240 CPPFYESDHP 250 VRVLDVLWIG 260 TYVFAIVYAA 270 ADGTLETSPD 280 VVMALLPKKE 290 EKHPEIFVNF 300 MEPCYGSCTE 310 RQHHYYLSYI 320 EEWDLVLAAS 330 AASTEVSILA 340 RQSDQINWES 350 WLLEDSSRAE 360 LPVTDKSDDS 370 LPMGVVVDYT 380 NQVEITISDE 390 KTLPPAPVLM 400 LLSTDGVLCP 410 FYMINQNPGV 420 KSLIKTPERL 430 SLEGERQPKS 440 PGSTPTTPTS 450 SQAPQKLDAS 460 AAAAPASLPP 470 SSPAAPIATF 480 SLLPAGGAPT 490 VFSFGSSSLK 500 SSATVTGEPP 510 SYSSGSDSSK 520 AAPGPGPSTF 530 SFVPPSKASL 540 APTPAASPVA 550 PSAASFSFGS 560 SGFKPTLEST 570 PVPSVSAPNI 580 AMKPSFPPST 590 SAVKVNLSEK 600 FTAAATSTPV 610 SSSQSAPPMS 620 PFSSASKPAA 630 SGPLSHPTPL 640 SAPPSSVPLK 650 SSVLPSPSGR 660 SAQGSSSPVP 670 SMVQKSPRIT 680 PPAAKPGSPQ 690 AKSLQPAVAE 700 KQGHQWKDSD 710 PVMAGIGEEI 720 AHFQKELEEL 730 KARTSKACFQ 740 VGTSEEMKML 750 RTESDDLHTF 760 LLEIKETTES 770 LHGDISSLKT 780 TLLEGFAGVE 790 EAREQNERNR 800 DSGYLHLLYK 810 RPLDPKSEAQ 820 LQEIRRLHQY 830 VKFAVQDVND 840 VLDLEWDQHL 850 EQKKKQRHLL 860 VPERETLFNT 870 LANNREIINQ 880 QRKRLNHLVD 890 SLQQLRLYKQ 900 TSLWSLSSAV 910 PSQSSIHSFD 920 SDLESLCNAL 930 LKTTIESHTK 940 SLPKVPAKLS 950 PMKQAQLRNF 960 LAKRKTPPVR 970 STAPASLSRS 980 AFLSQRYYED 990 LDEVSSTSSV 1000 SQSLESEDAR 1010 TSCKDDEAVV 1020 QAPRHAPVVR 1030 TPSIQPSLLP 1040 HAAPFAKSHL 1050 VHGSSPGVMG 1060 TSVATSASKI 1070 IPQGADSTML 1080 ATKTVKHGAP 1090 SPSHPISAPQ 1100 AAAAAALRRQ 1110 MASQAPAVNT 1120 LTESTLKNVP 1130 QVVNVQELKN 1140 NPATPSTAMG 1150 SSVPYSTAKT 1160 PHPVLTPVAA 1170 NQAKQGSLIN 1180 SLKPSGPTPA 1190 SGQLSSGDKA 1200 SGTAKIETAV 1210 TSTPSASGQF 1220 SKPFSFSPSG 1230 TGFNFGIITP 1240 TPSSNFTAAQ 1250 GATPSTKESS 1260 QPDAFSSGGG 1270 SKPSYEAIPE 1280 SSPPSGITSA 1290 SNTTPGEPAA 1300 SSSRPVAPSG 1310 TALSTTSSKL 1320 ETPPSKLGEL 1330 LFPSSLAGET 1340 LGSFSGLRVG 1350 QADDSTKPTN 1360 KASSTSLTST 1370 QPTKTSGVPS 1380 GFNFTAPPVL 1390 GKHTEPPVTS 1400 SATTTSVAPP 1410 AATSTSSTAV 1420 FGSLPVTSAG 1430 SSGVISFGGT 1440 SLSAGKTSFS 1450 FGSQQTNSTV 1460 PPSAPPPTTA 1470 ATPLPTSFPT 1480 LSFGSLLSSA 1490 TTPSLPMSAG 1500 RSTEEATSSA 1510 LPEKPGDSEV 1520 SASAASLLEE 1530 QQSAQLPQAP 1540 PQTSDSVKKE 1550 PVLAQPAVSN 1560 SGTAASSTSL 1570 VALSAEATPA 1580 TTGVPDARTE 1590 AVPPASSFSV 1600 PGQTAVTAAA 1610 ISSAGPVAVE 1620 TSSTPIASST 1630 TSIVAPGPSA 1640 EAAAFGTVTS 1650 GSSVFAQPPA 1660 ASSSSAFNQL 1670 TNNTATAPSA 1680 TPVFGQVAAS 1690 TAPSLFGQQT 1700 GSTASTAAAT 1710 PQVSSSGFSS 1720 PAFGTTAPGV 1730 FGQTTFGQAS 1740 VFGQSASSAA 1750 SVFSFSQPGF 1760 SSVPAFGQPA 1770 SSTPTSTSGS 1780 VFGAASSTSS 1790 SSSFSFGQSS 1800 PNTGGGLFGQ 1810 SNAPAFGQSP 1820 GFGQGGSVFG 1830 GTSAATTTAA 1840 TSGFSFCQAS 1850 GFGSSNTGSV 1860 FGQAASTGGI 1870 VFGQQSSSSS 1880 GSVFGSGNTG 1890 RGGGFFSGLG 1900 GKPSQDAANK 1910 NPFSSASGGF 1920 GSTATSNTSN 1930 LFGNSGAKTF 1940 GGFASSSFGE 1950 QKPTGTFSSG 1960 GGSVASQGFG 1970 FSSPNKTGGF 1980 GAAPVFGSPP 1990 TFGGSPGFGG 2000 VPAFGSAPAF 2010 TSPLGSTGGK 2020 VFGEGTAAAS 2030 AGGFGFGSSS 2040 NTTSFGTLAS 2050 QNAPTFGSLS 2060 QQTSGFGTQS 2070 SGFSGFGSGT 2080 GGFSFGSNNS 2090 SVQGFGGWRS

Gene Ontology

Classification GO ID Description
Cellular Component GO:1990876 cytoplasmic side of nuclear pore
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0005643 nuclear pore
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0005049 nuclear export signal receptor activity
Molecular Function GO:0008139 nuclear localization sequence binding
Molecular Function GO:0017056 structural constituent of nuclear pore
Biological Process GO:0006406 mRNA export from nucleus
Biological Process GO:0006913 nucleocytoplasmic transport
Biological Process GO:0006611 protein export from nucleus
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0046822 regulation of nucleocytoplasmic transport
Biological Process GO:0006405 RNA export from nucleus

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.