Search Results

Overview

Uniprot IDP35659
Protein NameProtein DEK
Gene NameDEK
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
278 SKSKKSVKSANVKKA
344 NLEEVTMKQICKKVY
349 TMKQICKKVYENYPT
57 KSLIVEGKREKKKVE
84 PFTIAQGKGQKLCEI

Function

Involved in chromatin organization

Protein Sequence

10 MSASAPAAEG 20 EGTPTQPASE 30 KEPEMPGPRE 40 ESEEEEDEDD 50 EEEEEEEKEK 60 SLIVEGKREK 70 KKVERLTMQV 80 SSLQREPFTI 90 AQGKGQKLCE 100 IERIHFFLSK 110 KKTDELRNLH 120 KLLYNRPGTV 130 SSLKKNVGQF 140 SGFPFEKGSV 150 QYKKKEEMLK 160 KFRNAMLKSI 170 CEVLDLERSG 180 VNSELVKRIL 190 NFLMHPKPSG 200 KPLPKSKKTC 210 SKGSKKERNS 220 SGMARKAKRT 230 KCPEILSDES 240 SSDEDEKKNK 250 EESSDDEDKE 260 SEEEPPKKTA 270 KREKPKQKAT 280 SKSKKSVKSA 290 NVKKADSSTT 300 KKNQNSSKKE 310 SESEDSSDDE 320 PLIKKLKKPP 330 TDEELKETIK 340 KLLASANLEE 350 VTMKQICKKV 360 YENYPTYDLT 370 ERKDFIKTTV KELIS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0043292 contractile muscle fiber
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0045943 positive regulation of transcription by RNA polymerase I
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0045945 positive regulation of transcription by RNA polymerase III
Biological Process GO:2000779 regulation of double-strand break repair
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0007165 signal transduction
Biological Process GO:0006366 transcription by RNA polymerase II
Biological Process GO:0019079 viral genome replication

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.