Overview
| Uniprot ID | P35700 |
|---|
| Protein Name | Peroxiredoxin-1 |
|---|
| Gene Name | Prdx1 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 178 |
EVCPAGWKPGSDTIK |
| 190 |
TIKPDVNKSKEYFSK |
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (PubMed:19766572)
Protein Sequence
10
MSSGNAKIGY
20
PAPNFKATAV
30
MPDGQFKDIS
40
LSEYKGKYVV
50
FFFYPLDFTF
60
VCPTEIIAFS
70
DRADEFKKLN
80
CQVIGASVDS
90
HFCHLAWINT
100
PKKQGGLGPM
110
NIPLISDPKR
120
TIAQDYGVLK
130
ADEGISFRGL
140
FIIDDKGILR
150
QITINDLPVG
160
RSVDEIIRLV
170
QAFQFTDKHG
180
EVCPAGWKPG
190
SDTIKPDVNK
SKEYFSKQK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0000791 |
euchromatin |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0043209 |
myelin sheath |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005782 |
peroxisomal matrix |
| Molecular Function |
GO:0020037 |
heme binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0004601 |
peroxidase activity |
| Molecular Function |
GO:0051920 |
peroxiredoxin activity |
| Molecular Function |
GO:0008379 |
thioredoxin peroxidase activity |
| Biological Process |
GO:0008283 |
cell population proliferation |
| Biological Process |
GO:0045454 |
cell redox homeostasis |
| Biological Process |
GO:0034101 |
erythrocyte homeostasis |
| Biological Process |
GO:0042744 |
hydrogen peroxide catabolic process |
| Biological Process |
GO:0045321 |
leukocyte activation |
| Biological Process |
GO:0030101 |
natural killer cell activation |
| Biological Process |
GO:0042267 |
natural killer cell mediated cytotoxicity |
| Biological Process |
GO:0032872 |
regulation of stress-activated MAPK cascade |
| Biological Process |
GO:0019430 |
removal of superoxide radicals |
| Biological Process |
GO:0006979 |
response to oxidative stress |
| Biological Process |
GO:0000302 |
response to reactive oxygen species |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.