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Overview

Uniprot IDP35711
Protein NameTranscription factor SOX-5
Gene NameSOX5
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
225 AAHDEQKKLAASQIE
233 LAASQIEKQRQQMEL

Function

Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene

Protein Sequence

10 MLTDPDLPQE 20 FERMSSKRPA 30 SPYGEADGEV 40 AMVTSRQKVE 50 EEESDGLPAF 60 HLPLHVSFPN 70 KPHSEEFQPV 80 SLLTQETCGH 90 RTPTSQHNTM 100 EVDGNKVMSS 110 FAPHNSSTSP 120 QKAEEGGRQS 130 GESLSSTALG 140 TPERRKGSLA 150 DVVDTLKQRK 160 MEELIKNEPE 170 ETPSIEKLLS 180 KDWKDKLLAM 190 GSGNFGEIKG 200 TPESLAEKER 210 QLMGMINQLT 220 SLREQLLAAH 230 DEQKKLAASQ 240 IEKQRQQMEL 250 AKQQQEQIAR 260 QQQQLLQQQH 270 KINLLQQQIQ 280 VQGQLPPLMI 290 PVFPPDQRTL 300 AAAAQQGFLL 310 PPGFSYKAGC 320 SDPYPVQLIP 330 TTMAAAAAAT 340 PGLGPLQLQQ 350 LYAAQLAAMQ 360 VSPGGKLPGI 370 PQGNLGAAVS 380 PTSIHTDKST 390 NSPPPKSKDE 400 VAQPLNLSAK 410 PKTSDGKSPT 420 SPTSPHMPAL 430 RINSGAGPLK 440 ASVPAALASP 450 SARVSTIGYL 460 NDHDAVTKAI 470 QEARQMKEQL 480 RREQQVLDGK 490 VAVVNSLGLN 500 NCRTEKEKTT 510 LESLTQQLAV 520 KQNEEGKFSH 530 AMMDFNLSGD 540 SDGSAGVSES 550 RIYRESRGRG 560 SNEPHIKRPM 570 NAFMVWAKDE 580 RRKILQAFPD 590 MHNSNISKIL 600 GSRWKAMTNL 610 EKQPYYEEQA 620 RLSKQHLEKY 630 PDYKYKPRPK 640 RTCLVDGKKL 650 RIGEYKAIMR 660 NRRQEMRQYF 670 NVGQQAQIPI 680 ATAGVVYPGA 690 IAMAGMPSPH 700 LPSEHSSVSS 710 SPEPGMPVIQ 720 STYGVKGEEP 730 HIKEEIQAED 740 INGEIYDEYD 750 EEEDDPDVDY 760 GSDSENHIAG QAN

Gene Ontology

Classification GO ID Description
Biological Process GO:0002062 chondrocyte differentiation
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0000976 transcription cis-regulatory region binding
Biological Process GO:0055059 asymmetric neuroblast division
Biological Process GO:0001502 cartilage condensation
Biological Process GO:0051216 cartilage development
Biological Process GO:0045165 cell fate commitment
Biological Process GO:0071560 cellular response to transforming growth factor beta stimulus
Biological Process GO:0061036 positive regulation of cartilage development
Biological Process GO:0032332 positive regulation of chondrocyte differentiation
Biological Process GO:2000741 positive regulation of mesenchymal stem cell differentiation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0006366 transcription by RNA polymerase II

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.