Search Results

Overview

Uniprot IDP35749
Protein NameMyosin-11
Gene NameMYH11
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1256 EVEHKKKKLEAQVQE
129 CVVVNPYKHLPIYSE
1813 GAVKSKFKSTIAALE
567 HPKFQKPKQLKDKTE
658 RTVGQLYKEQLGKLM
857 QEEEMQAKEDELQKT

Function

Muscle contraction

Protein Sequence

10 MAQKGQLSDD 20 EKFLFVDKNF 30 INSPVAQADW 40 AAKRLVWVPS 50 EKQGFEAASI 60 KEEKGDEVVV 70 ELVENGKKVT 80 VGKDDIQKMN 90 PPKFSKVEDM 100 AELTCLNEAS 110 VLHNLRERYF 120 SGLIYTYSGL 130 FCVVVNPYKH 140 LPIYSEKIVD 150 MYKGKKRHEM 160 PPHIYAIADT 170 AYRSMLQDRE 180 DQSILCTGES 190 GAGKTENTKK 200 VIQYLAVVAS 210 SHKGKKDTSI 220 TGELEKQLLQ 230 ANPILEAFGN 240 AKTVKNDNSS 250 RFGKFIRINF 260 DVTGYIVGAN 270 IETYLLEKSR 280 AIRQARDERT 290 FHIFYYMIAG 300 AKEKMRSDLL 310 LEGFNNYTFL 320 SNGFVPIPAA 330 QDDEMFQETV 340 EAMAIMGFSE 350 EEQLSILKVV 360 SSVLQLGNIV 370 FKKERNTDQA 380 SMPDNTAAQK 390 VCHLMGINVT 400 DFTRSILTPR 410 IKVGRDVVQK 420 AQTKEQADFA 430 VEALAKATYE 440 RLFRWILTRV 450 NKALDKTHRQ 460 GASFLGILDI 470 AGFEIFEVNS 480 FEQLCINYTN 490 EKLQQLFNHT 500 MFILEQEEYQ 510 REGIEWNFID 520 FGLDLQPCIE 530 LIERPNNPPG 540 VLALLDEECW 550 FPKATDKSFV 560 EKLCTEQGSH 570 PKFQKPKQLK 580 DKTEFSIIHY 590 AGKVDYNASA 600 WLTKNMDPLN 610 DNVTSLLNAS 620 SDKFVADLWK 630 DVDRIVGLDQ 640 MAKMTESSLP 650 SASKTKKGMF 660 RTVGQLYKEQ 670 LGKLMTTLRN 680 TTPNFVRCII 690 PNHEKRSGKL 700 DAFLVLEQLR 710 CNGVLEGIRI 720 CRQGFPNRIV 730 FQEFRQRYEI 740 LAANAIPKGF 750 MDGKQACILM 760 IKALELDPNL 770 YRIGQSKIFF 780 RTGVLAHLEE 790 ERDLKITDVI 800 MAFQAMCRGY 810 LARKAFAKRQ 820 QQLTAMKVIQ 830 RNCAAYLKLR 840 NWQWWRLFTK 850 VKPLLQVTRQ 860 EEEMQAKEDE 870 LQKTKERQQK 880 AENELKELEQ 890 KHSQLTEEKN 900 LLQEQLQAET 910 ELYAEAEEMR 920 VRLAAKKQEL 930 EEILHEMEAR 940 LEEEEDRGQQ 950 LQAERKKMAQ 960 QMLDLEEQLE 970 EEEAARQKLQ 980 LEKVTAEAKI 990 KKLEDEILVM 1000 DDQNNKLSKE 1010 RKLLEERISD 1020 LTTNLAEEEE 1030 KAKNLTKLKN 1040 KHESMISELE 1050 VRLKKEEKSR 1060 QELEKLKRKL 1070 EGDASDFHEQ 1080 IADLQAQIAE 1090 LKMQLAKKEE 1100 ELQAALARLD 1110 DEIAQKNNAL 1120 KKIRELEGHI 1130 SDLQEDLDSE 1140 RAARNKAEKQ 1150 KRDLGEELEA 1160 LKTELEDTLD 1170 STATQQELRA 1180 KREQEVTVLK 1190 KALDEETRSH 1200 EAQVQEMRQK 1210 HAQAVEELTE 1220 QLEQFKRAKA 1230 NLDKNKQTLE 1240 KENADLAGEL 1250 RVLGQAKQEV 1260 EHKKKKLEAQ 1270 VQELQSKCSD 1280 GERARAELND 1290 KVHKLQNEVE 1300 SVTGMLNEAE 1310 GKAIKLAKDV 1320 ASLSSQLQDT 1330 QELLQEETRQ 1340 KLNVSTKLRQ 1350 LEEERNSLQD 1360 QLDEEMEAKQ 1370 NLERHISTLN 1380 IQLSDSKKKL 1390 QDFASTVEAL 1400 EEGKKRFQKE 1410 IENLTQQYEE 1420 KAAAYDKLEK 1430 TKNRLQQELD 1440 DLVVDLDNQR 1450 QLVSNLEKKQ 1460 RKFDQLLAEE 1470 KNISSKYADE 1480 RDRAEAEARE 1490 KETKALSLAR 1500 ALEEALEAKE 1510 ELERTNKMLK 1520 AEMEDLVSSK 1530 DDVGKNVHEL 1540 EKSKRALETQ 1550 MEEMKTQLEE 1560 LEDELQATED 1570 AKLRLEVNMQ 1580 ALKGQFERDL 1590 QARDEQNEEK 1600 RRQLQRQLHE 1610 YETELEDERK 1620 QRALAAAAKK 1630 KLEGDLKDLE 1640 LQADSAIKGR 1650 EEAIKQLRKL 1660 QAQMKDFQRE 1670 LEDARASRDE 1680 IFATAKENEK 1690 KAKSLEADLM 1700 QLQEDLAAAE 1710 RARKQADLEK 1720 EELAEELASS 1730 LSGRNALQDE 1740 KRRLEARIAQ 1750 LEEELEEEQG 1760 NMEAMSDRVR 1770 KATQQAEQLS 1780 NELATERSTA 1790 QKNESARQQL 1800 ERQNKELRSK 1810 LHEMEGAVKS 1820 KFKSTIAALE 1830 AKIAQLEEQV 1840 EQEAREKQAA 1850 TKSLKQKDKK 1860 LKEILLQVED 1870 ERKMAEQYKE 1880 QAEKGNARVK 1890 QLKRQLEEAE 1900 EESQRINANR 1910 RKLQRELDEA 1920 TESNEAMGRE 1930 VNALKSKLRR 1940 GNETSFVPSR 1950 RSGGRRVIEN 1960 ADGSEEETDT 1970 RDADFNGTKA SE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0042470 melanosome
Cellular Component GO:0005859 muscle myosin complex
Cellular Component GO:0032982 myosin filament
Cellular Component GO:0016460 myosin II complex
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0000146 microfilament motor activity
Molecular Function GO:0008307 structural constituent of muscle
Biological Process GO:0031032 actomyosin structure organization
Biological Process GO:0055013 cardiac muscle cell development
Biological Process GO:0048251 elastic fiber assembly
Biological Process GO:0030241 skeletal muscle myosin thick filament assembly
Biological Process GO:0006939 smooth muscle contraction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.