Search Results

Overview

Uniprot IDP35750
Protein NameCalpain-1 catalytic subunit
Gene NameCAPN1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
24 QVQKLRAKELGLGRH
359 NLTPDALKSQRVRNW
583 KHKDLRTKGFSLESC
79 ELGPNSSKTYGVKWK

Function

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1. Cleaves and activates caspase-7 (CASP7)

Protein Sequence

10 MAEEVITPVY 20 CTGVSAQVQK 30 LRAKELGLGR 40 HENAIKYLGQ 50 DYEQLRAHCL 60 QSGSLFRDEA 70 FPPVPQSLGF 80 KELGPNSSKT 90 YGVKWKRPTE 100 LFSNPQFIVD 110 GATRTDICQG 120 ALGDCWLLAA 130 IASLTLNDTL 140 LHRVVPHGQS 150 FQNGYAGIFH 160 FQLWQFGEWV 170 DVVVDDLLPT 180 KDGKLVFVHS 190 AQGNEFWSAL 200 LEKAYAKVNG 210 SYEALSGGST 220 SEGFEDFTGG 230 VTEWYELRKA 240 PSDLYSIILK 250 ALERGSLLGC 260 SIDISSVLDM 270 EAVTFKKLVK 280 GHAYSVTGAK 290 QVNYQGQMVN 300 LIRMRNPWGE 310 VEWTGAWSDG 320 SSEWNGVDPY 330 QRDQLRVRME 340 DGEFWMSFRD 350 FLREFTRLEI 360 CNLTPDALKS 370 QRVRNWNTTL 380 YEGTWRRGST 390 AGGCRNYPAT 400 FWVNPQFKIR 410 LEETDDPEDD 420 YGGRESGCSF 430 VLALMQKHRR 440 RERRFGRDME 450 TIGFAVYEVP 460 PELVGQPVHL 470 KRDFFLANAS 480 RARSEQFINL 490 REVSTRFRLP 500 PGEYVVVPST 510 FEPNKEGDFV 520 LRFFSEKKAG 530 TQELDDQVQA 540 ILPDEQVLSE 550 EEIDENFKAL 560 FRQLAGEDME 570 ISVRELRTIL 580 NRIISKHKDL 590 RTKGFSLESC 600 RSMVNLMDRD 610 GNGKLGLVEF 620 NILWNRIRNY 630 LSIFRKFDLD 640 KSGSMSAYEM 650 RMAIESAGFK 660 LNKKLFELII 670 TRYSEPDLAV 680 DFDNFVCCLV 690 RLETMFRFFK 700 TLDTDLDGVV 710 TFDLFKWLQL TMFA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0004198 calcium-dependent cysteine-type endopeptidase activity
Biological Process GO:0006508 proteolysis
Biological Process GO:0050790 regulation of catalytic activity
Biological Process GO:0097264 self proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.