Search Results
Overview
| Uniprot ID | P35754 |
|---|---|
| Protein Name | Glutaredoxin-1 |
| Gene Name | GLRX |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 20 | GKVVVFIKPTCPYCR |
Function
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Protein Sequence
10
MAQEFVNCKI
20
QPGKVVVFIK
30
PTCPYCRRAQ
40
EILSQLPIKQ
50
GLLEFVDITA
60
TNHTNEIQDY
70
LQQLTGARTV
80
PRVFIGKDCI
90
GGCSDLVSLQ
100
QSGELLTRLK
QIGALQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0015038 | glutathione disulfide oxidoreductase activity |
| Molecular Function | GO:0017080 | sodium channel regulator activity |
| Biological Process | GO:0015949 | nucleobase-containing small molecule interconversion |
| Biological Process | GO:0045838 | positive regulation of membrane potential |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.