Search Results
Overview
| Uniprot ID | P35813 |
|---|---|
| Protein Name | Protein phosphatase 1A |
| Gene Name | PPM1A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 208 | DYKCVHGKGPTEQLV |
Function
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB
Protein Sequence
10
MGAFLDKPKM
20
EKHNAQGQGN
30
GLRYGLSSMQ
40
GWRVEMEDAH
50
TAVIGLPSGL
60
ESWSFFAVYD
70
GHAGSQVAKY
80
CCEHLLDHIT
90
NNQDFKGSAG
100
APSVENVKNG
110
IRTGFLEIDE
120
HMRVMSEKKH
130
GADRSGSTAV
140
GVLISPQHTY
150
FINCGDSRGL
160
LCRNRKVHFF
170
TQDHKPSNPL
180
EKERIQNAGG
190
SVMIQRVNGS
200
LAVSRALGDF
210
DYKCVHGKGP
220
TEQLVSPEPE
230
VHDIERSEED
240
DQFIILACDG
250
IWDVMGNEEL
260
CDFVRSRLEV
270
TDDLEKVCNE
280
VVDTCLYKGS
290
RDNMSVILIC
300
FPNAPKVSPE
310
AVKKEAELDK
320
YLECRVEEII
330
KKQGEGVPDL
340
VHVMRTLASE
350
NIPSLPPGGE
360
LASKRNVIEA
370
VYNRLNPYKN
380
DDTDSTSTDD
MW
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0033192 | calmodulin-dependent protein phosphatase activity |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0030145 | manganese ion binding |
| Molecular Function | GO:0004722 | protein serine/threonine phosphatase activity |
| Molecular Function | GO:0070412 | R-SMAD binding |
| Biological Process | GO:0006499 | N-terminal protein myristoylation |
| Biological Process | GO:0043124 | negative regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:1901223 | negative regulation of non-canonical NF-kappaB signal transduction |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0006470 | protein dephosphorylation |
| Biological Process | GO:0043122 | regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0051726 | regulation of cell cycle |
Reference
[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.