Search Results
Overview
| Uniprot ID | P35908 |
|---|---|
| Protein Name | Keratin, type II cytoskeletal 2 epidermal |
| Gene Name | KRT2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 286 | ENDFVTLKKDVDNAY |
| 287 | NDFVTLKKDVDNAYM |
| 414 | QGEIAHVKKQCKNVQ |
| 415 | GEIAHVKKQCKNVQD |
| 482 | VEIATYRKLLEGEEC |
Function
Structural component of intermediate filaments in suprabasal keratinocytes of stratified epidermis. Forms heteropolymers with type I keratins (e.g., KRT10), assembling into keratin intermediate filament networks that support mechanical integrity and resilience of the differentiating epidermis (PubMed:12598329, PubMed:1380918). Contributes to terminal differentiation and cornification of keratinocytes and plays a role in establishing the epidermal barrier (PubMed:9804344)
Protein Sequence
10
MSCQISCKSR
20
GRGGGGGGFR
30
GFSSGSAVVS
40
GGSRRSTSSF
50
SCLSRHGGGG
60
GGFGGGGFGS
70
RSLVGLGGTK
80
SISISVAGGG
90
GGFGAAGGFG
100
GRGGGFGGGS
110
SFGGGSGFSG
120
GGFGGGGFGG
130
GRFGGFGGPG
140
GVGGLGGPGG
150
FGPGGYPGGI
160
HEVSVNQSLL
170
QPLNVKVDPE
180
IQNVKAQERE
190
QIKTLNNKFA
200
SFIDKVRFLE
210
QQNQVLQTKW
220
ELLQQMNVGT
230
RPINLEPIFQ
240
GYIDSLKRYL
250
DGLTAERTSQ
260
NSELNNMQDL
270
VEDYKKKYED
280
EINKRTAAEN
290
DFVTLKKDVD
300
NAYMIKVELQ
310
SKVDLLNQEI
320
EFLKVLYDAE
330
ISQIHQSVTD
340
TNVILSMDNS
350
RNLDLDSIIA
360
EVKAQYEEIA
370
QRSKEEAEAL
380
YHSKYEELQV
390
TVGRHGDSLK
400
EIKIEISELN
410
RVIQRLQGEI
420
AHVKKQCKNV
430
QDAIADAEQR
440
GEHALKDARN
450
KLNDLEEALQ
460
QAKEDLARLL
470
RDYQELMNVK
480
LALDVEIATY
490
RKLLEGEECR
500
MSGDLSSNVT
510
VSVTSSTISS
520
NVASKAAFGG
530
SGGRGSSSGG
540
GYSSGSSSYG
550
SGGRQSGSRG
560
GSGGGGSISG
570
GGYGSGGGSG
580
GRYGSGGGSK
590
GGSISGGGYG
600
SGGGKHSSGG
610
GSRGGSSSGG
620
GYGSGGGGSS
630
SVKGSSGEAF
GSSVTFSFR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0070268 | cornification |
| Cellular Component | GO:0001533 | cornified envelope |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005882 | intermediate filament |
| Cellular Component | GO:0045095 | keratin filament |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0008092 | cytoskeletal protein binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Molecular Function | GO:0030280 | structural constituent of skin epidermis |
| Biological Process | GO:0008544 | epidermis development |
| Biological Process | GO:0045109 | intermediate filament organization |
| Biological Process | GO:0031424 | keratinization |
| Biological Process | GO:0032980 | keratinocyte activation |
| Biological Process | GO:0051546 | keratinocyte migration |
| Biological Process | GO:0043616 | keratinocyte proliferation |
| Biological Process | GO:0045684 | positive regulation of epidermis development |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.