Overview
| Uniprot ID | P36222 |
|---|
| Protein Name | Chitinase-3-like protein 1 |
|---|
| Gene Name | CHI3L1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 108 |
FGSQRFSKIASNTQS |
Function
Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung
Protein Sequence
10
MGVKASQTGF
20
VVLVLLQCCS
30
AYKLVCYYTS
40
WSQYREGDGS
50
CFPDALDRFL
60
CTHIIYSFAN
70
ISNDHIDTWE
80
WNDVTLYGML
90
NTLKNRNPNL
100
KTLLSVGGWN
110
FGSQRFSKIA
120
SNTQSRRTFI
130
KSVPPFLRTH
140
GFDGLDLAWL
150
YPGRRDKQHF
160
TTLIKEMKAE
170
FIKEAQPGKK
180
QLLLSAALSA
190
GKVTIDSSYD
200
IAKISQHLDF
210
ISIMTYDFHG
220
AWRGTTGHHS
230
PLFRGQEDAS
240
PDRFSNTDYA
250
VGYMLRLGAP
260
ASKLVMGIPT
270
FGRSFTLASS
280
ETGVGAPISG
290
PGIPGRFTKE
300
AGTLAYYEIC
310
DFLRGATVHR
320
ILGQQVPYAT
330
KGNQWVGYDD
340
QESVKSKVQY
350
LKDRQLAGAM
360
VWALDLDDFQ
370
GSFCGQDLRF
380
PLTNAIKDAL
AAT
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0031012 |
extracellular matrix |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0035580 |
specific granule lumen |
| Molecular Function |
GO:0030246 |
carbohydrate binding |
| Molecular Function |
GO:0008061 |
chitin binding |
| Molecular Function |
GO:0005201 |
extracellular matrix structural constituent |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0005975 |
carbohydrate metabolic process |
| Biological Process |
GO:0051216 |
cartilage development |
| Biological Process |
GO:0071356 |
cellular response to tumor necrosis factor |
| Biological Process |
GO:0006032 |
chitin catabolic process |
| Biological Process |
GO:0070371 |
ERK1 and ERK2 cascade |
| Biological Process |
GO:0006954 |
inflammatory response |
| Biological Process |
GO:0030324 |
lung development |
| Biological Process |
GO:0045766 |
positive regulation of angiogenesis |
| Biological Process |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
| Biological Process |
GO:0032757 |
positive regulation of interleukin-8 production |
| Biological Process |
GO:0051897 |
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process |
GO:0070555 |
response to interleukin-1 |
| Biological Process |
GO:0070741 |
response to interleukin-6 |
| Biological Process |
GO:0009612 |
response to mechanical stimulus |
| Biological Process |
GO:0034612 |
response to tumor necrosis factor |
| Biological Process |
GO:0032905 |
transforming growth factor beta1 production |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.