Overview
| Uniprot ID | P36404 |
|---|
| Protein Name | ADP-ribosylation factor-like protein 2 |
|---|
| Gene Name | ARL2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 8 |
MGLLTILKKMKQKER |
| 9 |
GLLTILKKMKQKERE |
Function
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle (PubMed:10831612, PubMed:16525022, PubMed:18234692, PubMed:18588884, PubMed:20740604). Also regulates mitochondrial integrity and function (PubMed:30945270)
Protein Sequence
10
MGLLTILKKM
20
KQKERELRLL
30
MLGLDNAGKT
40
TILKKFNGED
50
IDTISPTLGF
60
NIKTLEHRGF
70
KLNIWDVGGQ
80
KSLRSYWRNY
90
FESTDGLIWV
100
VDSADRQRMQ
110
DCQRELQSLL
120
VEERLAGATL
130
LIFANKQDLP
140
GALSSNAIRE
150
VLELDSIRSH
160
HWCIQGCSAV
170
TGENLLPGID
180
WLLDDISSRI
FTAD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016328 |
lateral plasma membrane |
| Cellular Component |
GO:0015630 |
microtubule cytoskeleton |
| Cellular Component |
GO:0005758 |
mitochondrial intermembrane space |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0019003 |
GDP binding |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Biological Process |
GO:0070830 |
bicellular tight junction assembly |
| Biological Process |
GO:0007098 |
centrosome cycle |
| Biological Process |
GO:0051457 |
maintenance of protein location in nucleus |
| Biological Process |
GO:0034260 |
negative regulation of GTPase activity |
| Biological Process |
GO:0010811 |
positive regulation of cell-substrate adhesion |
| Biological Process |
GO:0031116 |
positive regulation of microtubule polymerization |
| Biological Process |
GO:0006457 |
protein folding |
| Biological Process |
GO:1903715 |
regulation of aerobic respiration |
| Biological Process |
GO:0006110 |
regulation of glycolytic process |
| Biological Process |
GO:0031113 |
regulation of microtubule polymerization |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.