Search Results
Overview
| Uniprot ID | P36507 |
|---|---|
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 2 |
| Gene Name | MAP2K2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 101 | SGLIMARKLIHLEIK |
Function
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126)
Protein Sequence
10
MLARRKPVLP
20
ALTINPTIAE
30
GPSPTSEGAS
40
EANLVDLQKK
50
LEELELDEQQ
60
KKRLEAFLTQ
70
KAKVGELKDD
80
DFERISELGA
90
GNGGVVTKVQ
100
HRPSGLIMAR
110
KLIHLEIKPA
120
IRNQIIRELQ
130
VLHECNSPYI
140
VGFYGAFYSD
150
GEISICMEHM
160
DGGSLDQVLK
170
EAKRIPEEIL
180
GKVSIAVLRG
190
LAYLREKHQI
200
MHRDVKPSNI
210
LVNSRGEIKL
220
CDFGVSGQLI
230
DSMANSFVGT
240
RSYMAPERLQ
250
GTHYSVQSDI
260
WSMGLSLVEL
270
AVGRYPIPPP
280
DAKELEAIFG
290
RPVVDGEEGE
300
PHSISPRPRP
310
PGRPVSGHGM
320
DSRPAMAIFE
330
LLDYIVNEPP
340
PKLPNGVFTP
350
DFQEFVNKCL
360
IKNPAERADL
370
KMLTNHTFIK
380
RSEVEEVDFA
390
GWLCKTLRLN
400
QPGTPTRTAV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005911 | cell-cell junction |
| Molecular Function | GO:0005078 | MAP-kinase scaffold activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0030165 | PDZ domain binding |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0043539 | protein serine/threonine kinase activator activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Molecular Function | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| Molecular Function | GO:0004713 | protein tyrosine kinase activity |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Biological Process | GO:0038133 | ERBB2-ERBB3 signaling pathway |
| Biological Process | GO:0070371 | ERK1 and ERK2 cascade |
| Biological Process | GO:0048009 | insulin-like growth factor receptor signaling pathway |
| Biological Process | GO:0000165 | MAPK cascade |
| Biological Process | GO:0042552 | myelination |
| Biological Process | GO:0036289 | peptidyl-serine autophosphorylation |
| Biological Process | GO:2000147 | positive regulation of cell motility |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| Biological Process | GO:2000641 | regulation of early endosome to late endosome transport |
| Biological Process | GO:0090170 | regulation of Golgi inheritance |
| Biological Process | GO:0032872 | regulation of stress-activated MAPK cascade |
| Biological Process | GO:0014044 | Schwann cell development |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005770 | late endosome |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005778 | peroxisomal membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004708 | MAP kinase kinase activity |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.