Search Results

Overview

Uniprot IDP36537
Protein NameUDP-glucuronosyltransferase 2B10
Gene NameUGT2B10
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
127 DIIRNFCKDVVSNKK
133 CKDVVSNKKLMKKLQ
329 VIATALAKIPQKVLW
342 LWRFDGNKPDALGLN
43 MNMKTILKELVQRGH
438 VINDPSYKENIMKLS
443 SYKENIMKLSRIQHD

Function

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:17576790, PubMed:18238858, PubMed:28803208). Specialized in N-glucuronidation of tertiary amine-containing drugs and xenobiotics (PubMed:20133892, PubMed:28803208). Catalyzes N-glucuronidation of tobacco alkaloids, tobacco-specific nitrosamines, tricyclic antidepressants and compounds containing imidazole groups (PubMed:17576790, PubMed:18238858, PubMed:18300939, PubMed:20133892, PubMed:28803208). Major enzyme responsible for detoxification of tobacco-specific nitrosamines (PubMed:18238858, PubMed:18300939). Shows strong preference for tertiary aliphatic and cyclic amines over secondary or primary amines (PubMed:20133892, PubMed:28803208). Does not glucuronidate steroids, hyodeoxycholic acid, or phenolic xenobiotics (PubMed:8333863)

Protein Sequence

10 MALKWTTVLL 20 IQLSFYFSSG 30 SCGKVLVWAA 40 EYSLWMNMKT 50 ILKELVQRGH 60 EVTVLASSAS 70 ILFDPNDSST 80 LKLEVYPTSL 90 TKTEFENIIM 100 QLVKRLSEIQ 110 KDTFWLPFSQ 120 EQEILWAIND 130 IIRNFCKDVV 140 SNKKLMKKLQ 150 ESRFDIVFAD 160 AYLPCGELLA 170 ELFNIPFVYS 180 HSFSPGYSFE 190 RHSGGFIFPP 200 SYVPVVMSKL 210 SDQMTFMERV 220 KNMLYVLYFD 230 FWFQIFNMKK 240 WDQFYSEVLG 250 RPTTLSETMR 260 KADIWLMRNS 270 WNFKFPHPFL 280 PNVDFVGGLH 290 CKPAKPLPKE 300 MEEFVQSSGE 310 NGVVVFSLGS 320 MVSNMTEERA 330 NVIATALAKI 340 PQKVLWRFDG 350 NKPDALGLNT 360 RLYKWIPQND 370 LLGHPKTRAF 380 ITHGGANGIY 390 EAIYHGIPMV 400 GIPLFFDQPD 410 NIAHMKAKGA 420 AVRVDFNTMS 430 STDLLNALKT 440 VINDPSYKEN 450 IMKLSRIQHD 460 QPVKPLDRAV 470 FWIEFVMRHK 480 GAKHLRVAAH 490 NLTWFQYHSL 500 DVIGFLLACV 510 ATVLFIITKC 520 CLFCFWKFAR KGKKGKRD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Molecular Function GO:0008194 UDP-glycosyltransferase activity
Biological Process GO:0008210 estrogen metabolic process
Biological Process GO:0006629 lipid metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.