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Overview

Uniprot IDP36542
Protein NameATP synthase F(1) complex subunit gamma, mitochondrial
Gene NameATP5F1C
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
112 AIHSSIAKQMKSEVA
115 SSIAKQMKSEVATLT
136 MLVGIGDKIRGILYR
154 DQFLVAFKEVGRKPP
39 TRRLKSIKNIQKITK
46 KNIQKITKSMKMVAA
49 QKITKSMKMVAAAKY
55 MKMVAAAKYARAERE
79 GSLALYEKADIKGPE
83 LYEKADIKGPEDKKK
90 KGPEDKKKHLLIGVS

Function

Subunit gamma, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the central stalk subunit delta, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate (PubMed:29499186)

Protein Sequence

10 MFSRAGVAGL 20 SAWTLQPQWI 30 QVRNMATLKD 40 ITRRLKSIKN 50 IQKITKSMKM 60 VAAAKYARAE 70 RELKPARIYG 80 LGSLALYEKA 90 DIKGPEDKKK 100 HLLIGVSSDR 110 GLCGAIHSSI 120 AKQMKSEVAT 130 LTAAGKEVML 140 VGIGDKIRGI 150 LYRTHSDQFL 160 VAFKEVGRKP 170 PTFGDASVIA 180 LELLNSGYEF 190 DEGSIIFNKF 200 RSVISYKTEE 210 KPIFSLNTVA 220 SADSMSIYDD 230 IDADVLQNYQ 240 EYNLANIIYY 250 SLKESTTSEQ 260 SARMTAMDNA 270 SKNASEMIDK 280 LTLTFNRTRQ 290 AVITKELIEI ISGAAALD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0045259 proton-transporting ATP synthase complex
Molecular Function GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006754 ATP biosynthetic process
Biological Process GO:0006119 oxidative phosphorylation
Biological Process GO:0015986 proton motive force-driven ATP synthesis
Biological Process GO:0042776 proton motive force-driven mitochondrial ATP synthesis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.