Overview
| Uniprot ID | P36543 |
|---|
| Protein Name | V-type proton ATPase subunit E 1 |
|---|
| Gene Name | ATP6V1E1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 10 |
LSDADVQKQIKHMMA |
| 138 |
RMIVRCRKQDFPLVK |
| 52 |
LVQTQRLKIMEYYEK |
| 99 |
TDLLNEAKQRLSKVV |
Function
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32001091, PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:32001091). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (PubMed:22053050, PubMed:39695235)
Protein Sequence
10
MALSDADVQK
20
QIKHMMAFIE
30
QEANEKAEEI
40
DAKAEEEFNI
50
EKGRLVQTQR
60
LKIMEYYEKK
70
EKQIEQQKKI
80
QMSNLMNQAR
90
LKVLRARDDL
100
ITDLLNEAKQ
110
RLSKVVKDTT
120
RYQVLLDGLV
130
LQGLYQLLEP
140
RMIVRCRKQD
150
FPLVKAAVQK
160
AIPMYKIATK
170
NDVDVQIDQE
180
SYLPEDIAGG
190
VEIYNGDRKI
200
KVSNTLESRL
210
DLIAQQMMPE
220
VRGALFGANA
NRKFLD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0030665 |
clathrin-coated vesicle membrane |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005768 |
endosome |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0005902 |
microvillus |
| Cellular Component |
GO:0016469 |
proton-transporting two-sector ATPase complex |
| Cellular Component |
GO:0030672 |
synaptic vesicle membrane |
| Cellular Component |
GO:0000221 |
vacuolar proton-transporting V-type ATPase, V1 domain |
| Molecular Function |
GO:0051117 |
ATPase binding |
| Molecular Function |
GO:0046961 |
proton-transporting ATPase activity, rotational mechanism |
| Biological Process |
GO:1902600 |
proton transmembrane transport |
| Biological Process |
GO:0016241 |
regulation of macroautophagy |
| Biological Process |
GO:0097401 |
synaptic vesicle lumen acidification |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.