Search Results
Overview
| Uniprot ID | P36551 |
|---|---|
| Protein Name | Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial |
| Gene Name | CPOX |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 404 | LLYDRGTKFGLFTPG |
Function
Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX and participates to the sixth step in the heme biosynthetic pathway
Protein Sequence
10
MALQLGRLSS
20
GPCWLVARGG
30
CGGPRAWSQC
40
GGGGLRAWSQ
50
RSAAGRVCRP
60
PGPAGTEQSR
70
GLGHGSTSRG
80
GPWVGTGLAA
90
ALAGLVGLAT
100
AAFGHVQRAE
110
MLPKTSGTRA
120
TSLGRPEEEE
130
DELAHRCSSF
140
MAPPVTDLGE
150
LRRRPGDMKT
160
KMELLILETQ
170
AQVCQALAQV
180
DGGANFSVDR
190
WERKEGGGGI
200
SCVLQDGCVF
210
EKAGVSISVV
220
HGNLSEEAAK
230
QMRSRGKVLK
240
TKDGKLPFCA
250
MGVSSVIHPK
260
NPHAPTIHFN
270
YRYFEVEEAD
280
GNKQWWFGGG
290
CDLTPTYLNQ
300
EDAVHFHRTL
310
KEACDQHGPD
320
LYPKFKKWCD
330
DYFFIAHRGE
340
RRGIGGIFFD
350
DLDSPSKEEV
360
FRFVQSCARA
370
VVPSYIPLVK
380
KHCDDSFTPQ
390
EKLWQQLRRG
400
RYVEFNLLYD
410
RGTKFGLFTP
420
GSRIESILMS
430
LPLTARWEYM
440
HSPSENSKEA
450
EILEVLRHPR
DWVR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Biological Process | GO:0010288 | response to lead ion |
| Biological Process | GO:0051597 | response to methylmercury |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005758 | mitochondrial intermembrane space |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004109 | coproporphyrinogen oxidase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0005212 | structural constituent of eye lens |
| Biological Process | GO:0006784 | heme A biosynthetic process |
| Biological Process | GO:0006785 | heme B biosynthetic process |
| Biological Process | GO:0006783 | heme biosynthetic process |
| Biological Process | GO:0006782 | protoporphyrinogen IX biosynthetic process |
| Biological Process | GO:0046685 | response to arsenic-containing substance |
| Biological Process | GO:0017085 | response to insecticide |
| Biological Process | GO:0010039 | response to iron ion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.