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Overview

Uniprot IDP36871
Protein NamePhosphoglucomutase-1
Gene NamePGM1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
16 TQAYQDQKPGTSGLR
172 VDLGVLGKQQFDLEN
234 GVVGPYVKKILCEEL
3 *****MVKIVTVKTQ
349 DRVASATKIALYETP
406 LSILATRKQSVEDIL
419 ILKDHWQKYGRNFFT
440 VEAEGANKMMKDLEA
457 FDRSFVGKQFSANDK
464 KQFSANDKVYTVEKA
523 LYIDSYEKDVAKINQ
8 MVKIVTVKTQAYQDQ

Function

Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:15378030, PubMed:25288802). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (Probable) (PubMed:25288802). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:17924679, PubMed:25288802)

Protein Sequence

10 MVKIVTVKTQ 20 AYQDQKPGTS 30 GLRKRVKVFQ 40 SSANYAENFI 50 QSIISTVEPA 60 QRQEATLVVG 70 GDGRFYMKEA 80 IQLIARIAAA 90 NGIGRLVIGQ 100 NGILSTPAVS 110 CIIRKIKAIG 120 GIILTASHNP 130 GGPNGDFGIK 140 FNISNGGPAP 150 EAITDKIFQI 160 SKTIEEYAVC 170 PDLKVDLGVL 180 GKQQFDLENK 190 FKPFTVEIVD 200 SVEAYATMLR 210 SIFDFSALKE 220 LLSGPNRLKI 230 RIDAMHGVVG 240 PYVKKILCEE 250 LGAPANSAVN 260 CVPLEDFGGH 270 HPDPNLTYAA 280 DLVETMKSGE 290 HDFGAAFDGD 300 GDRNMILGKH 310 GFFVNPSDSV 320 AVIAANIFSI 330 PYFQQTGVRG 340 FARSMPTSGA 350 LDRVASATKI 360 ALYETPTGWK 370 FFGNLMDASK 380 LSLCGEESFG 390 TGSDHIREKD 400 GLWAVLAWLS 410 ILATRKQSVE 420 DILKDHWQKY 430 GRNFFTRYDY 440 EEVEAEGANK 450 MMKDLEALMF 460 DRSFVGKQFS 470 ANDKVYTVEK 480 ADNFEYSDPV 490 DGSISRNQGL 500 RLIFTDGSRI 510 VFRLSGTGSA 520 GATIRLYIDS 530 YEKDVAKINQ 540 DPQVMLAPLI 550 SIALKVSQLQ 560 ERTGRTAPTV IT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:1904724 tertiary granule lumen
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0004614 phosphoglucomutase activity
Biological Process GO:0005975 carbohydrate metabolic process
Biological Process GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:0005980 glycogen catabolic process
Biological Process GO:0006096 glycolytic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.