Search Results
Overview
| Uniprot ID | P36876 |
|---|---|
| Protein Name | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform |
| Gene Name | Ppp2r2a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 404 | VCASGKRKKDEISVD |
| 405 | CASGKRKKDEISVDS |
Function
Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (By similarity)
Protein Sequence
10
MAGAGGGNDI
20
QWCFSQVKGA
30
VDDDVAEADI
40
ISTVEFNHSG
50
ELLATGDKGG
60
RVVIFQQEQE
70
NKIQSHSRGE
80
YNVYSTFQSH
90
EPEFDYLKSL
100
EIEEKINKIR
110
WLPQKNAAQF
120
LLSTNDKTIK
130
LWKISERDKR
140
PEGYNLKEED
150
GRYRDPTTVT
160
TLRVPVFRPM
170
DLMVEASPRR
180
IFANAHTYHI
190
NSISINSDYE
200
TYLSADDLRI
210
NLWHLEITDR
220
SFNIVDIKPA
230
NMEELTEVIT
240
AAEFHPNSCN
250
TFVYSSSKGT
260
IRLCDMRASA
270
LCDRHSKLFE
280
EPEDPSNRSF
290
FSEIISSISD
300
VKFSHSGRYM
310
MTRDYLSVKV
320
WDLNMENRPV
330
ETYQVHEYLR
340
SKLCSLYEND
350
CIFDKFECCW
360
NGSDSVVMTG
370
SYNNFFRMFD
380
RNTKRDITLE
390
ASRENNKPRT
400
VLKPRKVCAS
410
GKRKKDEISV
420
DSLDFNKKIL
430
HTAWHPKENI
440
IAVATTNNLY
IFQDKVN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0000159 | protein phosphatase type 2A complex |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0140767 | enzyme-substrate adaptor activity |
| Molecular Function | GO:0051721 | protein phosphatase 2A binding |
| Molecular Function | GO:0019888 | protein phosphatase regulator activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0048156 | tau protein binding |
| Biological Process | GO:0006470 | protein dephosphorylation |
| Biological Process | GO:0051983 | regulation of chromosome segregation |
| Biological Process | GO:0043278 | response to morphine |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.