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Overview

Uniprot ID	P36915
Protein Name	Guanine nucleotide-binding protein-like 1
Gene Name	GNL1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
12	KPFSVKQKKKQLQDK

Function

Possible regulatory or functional link with the histocompatibility cluster

Protein Sequence

10 MPRKKPFSVK 20 QKKKQLQDKR 30 ERKRGLQDGL 40 RSSSNSRSGS 50 RERREEQTDT 60 SDGESVTHHI 70 RRLNQQPSQG 80 LGPRGYDPNR 90 YRLHFERDSR 100 EEVERRKRAA 110 REQVLQPVSA 120 ELLELDIREV 130 YQPGSVLDFP 140 RRPPWSYEMS 150 KEQLMSQEER 160 SFQDYLGKIH 170 GAYSSEKLSY 180 FEHNLETWRQ 190 LWRVLEMSDI 200 VLLITDIRHP 210 VVNFPPALYE 220 YVTGELGLAL 230 VLVLNKVDLA 240 PPALVVAWKH 250 YFHQHYPQLH 260 VVLFTSFPRD 270 PRTPQDPSSV 280 LKKSRRRGRG 290 WTRALGPEQL 300 LRACEAITVG 310 KVDLSSWREK 320 IARDVAGATW 330 GNGSGEEEEE 340 EDGPAVLVEQ 350 QTDSAMEPTG 360 PTQERYKDGV 370 VTIGCVGFPN 380 VGKSSLINGL 390 VGRKVVSVSR 400 TPGHTRYFQT 410 YFLTPSVKLC 420 DCPGLIFPSL 430 LPRQLQVLAG 440 IYPIAQIQEP 450 YTAVGYLASR 460 IPVQALLHLR 470 HPEAEDPSAE 480 HPWCAWDICE 490 AWAEKRGYKT 500 AKAARNDVYR 510 AANSLLRLAV 520 DGRLSLCFHP 530 PGYSEQKGTW 540 ESHPETTELV 550 VLQGRVGPAG 560 DEEEEEEEEL 570 SSSCEEEGEE 580 DRDADEEGEG 590 DEETPTSAPG 600 SSLAGRNPYA LLGEDEC

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:0005198	structural molecule activity
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0002456	T cell mediated immunity

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.