Search Results
Overview
| Uniprot ID | P36955 |
|---|---|
| Protein Name | Pigment epithelium-derived factor |
| Gene Name | SERPINF1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 160 | SFVAPLEKSYGTRPR |
| 316 | QAVLTVPKLKLSYEG |
| 327 | SYEGEVTKSLQEMKL |
Function
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity
Protein Sequence
10
MQALVLLLCI
20
GALLGHSSCQ
30
NPASPPEEGS
40
PDPDSTGALV
50
EEEDPFFKVP
60
VNKLAAAVSN
70
FGYDLYRVRS
80
STSPTTNVLL
90
SPLSVATALS
100
ALSLGAEQRT
110
ESIIHRALYY
120
DLISSPDIHG
130
TYKELLDTVT
140
APQKNLKSAS
150
RIVFEKKLRI
160
KSSFVAPLEK
170
SYGTRPRVLT
180
GNPRLDLQEI
190
NNWVQAQMKG
200
KLARSTKEIP
210
DEISILLLGV
220
AHFKGQWVTK
230
FDSRKTSLED
240
FYLDEERTVR
250
VPMMSDPKAV
260
LRYGLDSDLS
270
CKIAQLPLTG
280
SMSIIFFLPL
290
KVTQNLTLIE
300
ESLTSEFIHD
310
IDRELKTVQA
320
VLTVPKLKLS
330
YEGEVTKSLQ
340
EMKLQSLFDS
350
PDFSKITGKP
360
IKLTQVEHRA
370
GFEWNEDGAG
380
TTPSPGLQPA
390
HLTFPLDYHL
400
NQPFIFVLRD
410
TDTGALLFIG
KILDPRGP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0071279 | cellular response to cobalt ion |
| Cellular Component | GO:0043203 | axon hillock |
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Biological Process | GO:0071549 | cellular response to dexamethasone stimulus |
| Biological Process | GO:0071333 | cellular response to glucose stimulus |
| Biological Process | GO:0071300 | cellular response to retinoic acid |
| Biological Process | GO:0001822 | kidney development |
| Biological Process | GO:0016525 | negative regulation of angiogenesis |
| Biological Process | GO:0010596 | negative regulation of endothelial cell migration |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0042698 | ovulation cycle |
| Biological Process | GO:0050769 | positive regulation of neurogenesis |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:0010447 | response to acidic pH |
| Biological Process | GO:0046685 | response to arsenic-containing substance |
| Biological Process | GO:1901652 | response to peptide |
| Biological Process | GO:0060041 | retina development in camera-type eye |
| Biological Process | GO:0007614 | short-term memory |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.