Search Results

Overview

Uniprot IDP36957
Protein NameDihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Gene NameDLST
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
154 GAAPAKAKPAEAPAA
203 GKPVSAVKPTVAPPL
217 LAEPGAGKGLRSEHR
239 QRIAQRLKEAQNTCA
267 QEMRARHKEAFLKKH
353 TITELGEKARKNELA
74 KDDLVTVKTPAFAES

Function

Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711, PubMed:30929736). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711)

Protein Sequence

10 MLSRSRCVSR 20 AFSRSLSAFQ 30 KGNCPLGRRS 40 LPGVSLCQGP 50 GYPNSRKVVI 60 NNSVFSVRFF 70 RTTAVCKDDL 80 VTVKTPAFAE 90 SVTEGDVRWE 100 KAVGDTVAED 110 EVVCEIETDK 120 TSVQVPSPAN 130 GVIEALLVPD 140 GGKVEGGTPL 150 FTLRKTGAAP 160 AKAKPAEAPA 170 AAAPKAEPTA 180 AAVPPPAAPI 190 PTQMPPVPSP 200 SQPPSGKPVS 210 AVKPTVAPPL 220 AEPGAGKGLR 230 SEHREKMNRM 240 RQRIAQRLKE 250 AQNTCAMLTT 260 FNEIDMSNIQ 270 EMRARHKEAF 280 LKKHNLKLGF 290 MSAFVKASAF 300 ALQEQPVVNA 310 VIDDTTKEVV 320 YRDYIDISVA 330 VATPRGLVVP 340 VIRNVEAMNF 350 ADIERTITEL 360 GEKARKNELA 370 IEDMDGGTFT 380 ISNGGVFGSL 390 FGTPIINPPQ 400 SAILGMHGIF 410 DRPVAIGGKV 420 EVRPMMYVAL 430 TYDHRLIDGR 440 EAVTFLRKIK 450 AAVEDPRVLL LDL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0160167 oxoadipate dehydrogenase complex
Cellular Component GO:0045252 oxoglutarate dehydrogenase complex
Molecular Function GO:0016746 acyltransferase activity
Molecular Function GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity
Biological Process GO:0120551 2-oxoglutarate decarboxylation to succinyl-CoA
Biological Process GO:0006103 2-oxoglutarate metabolic process
Biological Process GO:0006091 generation of precursor metabolites and energy
Biological Process GO:0033512 L-lysine catabolic process to acetyl-CoA via L-saccharopine
Biological Process GO:0006104 succinyl-CoA metabolic process
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.