Search Results
Overview
| Uniprot ID | P36980 |
|---|---|
| Protein Name | Complement factor H-related protein 2 |
| Gene Name | CFHR2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 139 | RGWSTPPKCRSTISA |
| 222 | EKYNIKLKWTNQQKL |
Function
Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism
Protein Sequence
10
MWLLVSVILI
20
SRISSVGGEA
30
MFCDFPKINH
40
GILYDEEKYK
50
PFSQVPTGEV
60
FYYSCEYNFV
70
SPSKSFWTRI
80
TCAEEGWSPT
90
PKCLRLCFFP
100
FVENGHSESS
110
GQTHLEGDTV
120
QIICNTGYRL
130
QNNENNISCV
140
ERGWSTPPKC
150
RSTISAEKCG
160
PPPPIDNGDI
170
TSFLLSVYAP
180
GSSVEYQCQN
190
LYQLEGNNQI
200
TCRNGQWSEP
210
PKCLDPCVIS
220
QEIMEKYNIK
230
LKWTNQQKLY
240
SRTGDIVEFV
250
CKSGYHPTKS
260
HSFRAMCQNG
270
KLVYPSCEEK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0001851 | complement component C3b binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0006956 | complement activation |
| Biological Process | GO:0051838 | cytolysis by host of symbiont cells |
| Biological Process | GO:0032091 | negative regulation of protein binding |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.