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Overview

Uniprot IDP37275
Protein NameZinc finger E-box-binding homeobox 1
Gene NameZEB1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
223 ERHMTSHKSGRDQRH
290 YSSHISSKKCISLIP
291 SSHISSKKCISLIPV
331 TRPQIRQKIENKPLQ

Function

Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity)

Protein Sequence

10 MADGPRCKRR 20 KQANPRRNNV 30 TNYNTVVETN 40 SDSDDEDKLH 50 IVEEESVTDA 60 ADCEGVPEDD 70 LPTDQTVLPG 80 RSSEREGNAK 90 NCWEDDRKEG 100 QEILGPEAQA 110 DEAGCTVKDD 120 ECESDAENEQ 130 NHDPNVEEFL 140 QQQDTAVIFP 150 EAPEEDQRQG 160 TPEASGHDEN 170 GTPDAFSQLL 180 TCPYCDRGYK 190 RFTSLKEHIK 200 YRHEKNEDNF 210 SCSLCSYTFA 220 YRTQLERHMT 230 SHKSGRDQRH 240 VTQSGCNRKF 250 KCTECGKAFK 260 YKHHLKEHLR 270 IHSGEKPYEC 280 PNCKKRFSHS 290 GSYSSHISSK 300 KCISLIPVNG 310 RPRTGLKTSQ 320 CSSPSLSASP 330 GSPTRPQIRQ 340 KIENKPLQEQ 350 LSVNQIKTEP 360 VDYEFKPIVV 370 ASGINCSTPL 380 QNGVFTGGGP 390 LQATSSPQGM 400 VQAVVLPTVG 410 LVSPISINLS 420 DIQNVLKVAV 430 DGNVIRQVLE 440 NNQANLASKE 450 QETINASPIQ 460 QGGHSVISAI 470 SLPLVDQDGT 480 TKIIINYSLE 490 QPSQLQVVPQ 500 NLKKENPVAT 510 NSCKSEKLPE 520 DLTVKSEKDK 530 SFEGGVNDST 540 CLLCDDCPGD 550 INALPELKHY 560 DLKQPTQPPP 570 LPAAEAEKPE 580 SSVSSATGDG 590 NLSPSQPPLK 600 NLLSLLKAYY 610 ALNAQPSAEE 620 LSKIADSVNL 630 PLDVVKKWFE 640 KMQAGQISVQ 650 SSEPSSPEPG 660 KVNIPAKNND 670 QPQSANANEP 680 QDSTVNLQSP 690 LKMTNSPVLP 700 VGSTTNGSRS 710 STPSPSPLNL 720 SSSRNTQGYL 730 YTAEGAQEEP 740 QVEPLDLSLP 750 KQQGELLERS 760 TITSVYQNSV 770 YSVQEEPLNL 780 SCAKKEPQKD 790 SCVTDSEPVV 800 NVIPPSANPI 810 NIAIPTVTAQ 820 LPTIVAIADQ 830 NSVPCLRALA 840 ANKQTILIPQ 850 VAYTYSTTVS 860 PAVQEPPLKV 870 IQPNGNQDER 880 QDTSSEGVSN 890 VEDQNDSDST 900 PPKKKMRKTE 910 NGMYACDLCD 920 KIFQKSSSLL 930 RHKYEHTGKR 940 PHECGICKKA 950 FKHKHHLIEH 960 MRLHSGEKPY 970 QCDKCGKRFS 980 HSGSYSQHMN 990 HRYSYCKREA 1000 EERDSTEQEE 1010 AGPEILSNEH 1020 VGARASPSQG 1030 DSDERESLTR 1040 EEDEDSEKEE 1050 EEEDKEMEEL 1060 QEEKECEKPQ 1070 GDEEEEEEEE 1080 EVEEEEVEEA 1090 ENEGEEAKTE 1100 GLMKDDRAES 1110 QASSLGQKVG 1120 ESSEQVSEEK TNEA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0070888 E-box binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0030154 cell differentiation
Biological Process GO:0007417 central nervous system development
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0045602 negative regulation of endothelial cell differentiation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045666 positive regulation of neuron differentiation
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.