Search Results
Overview
| Uniprot ID | P37361 |
|---|---|
| Protein Name | Metallothionein-3 |
| Gene Name | Mt3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 32 | CKCTNCKKSCCSCCP |
| 44 | CCPAGCEKCAKDCVC |
| 52 | CAKDCVCKGEEGAKA |
Function
Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity)
Protein Sequence
10
MDPETCPCPT
20
GGSCTCSDKC
30
KCKGCKCTNC
40
KKSCCSCCPA
50
GCEKCAKDCV
60
CKGEEGAKAE
KCSCCQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0097450 | astrocyte end-foot |
| Cellular Component | GO:0097449 | astrocyte projection |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0016234 | inclusion body |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005840 | ribosome |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Molecular Function | GO:0046870 | cadmium ion binding |
| Molecular Function | GO:0005507 | copper ion binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0030295 | protein kinase activator activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0032148 | activation of protein kinase B activity |
| Biological Process | GO:1990748 | cellular detoxification |
| Biological Process | GO:0071276 | cellular response to cadmium ion |
| Biological Process | GO:0071280 | cellular response to copper ion |
| Biological Process | GO:0071456 | cellular response to hypoxia |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0034614 | cellular response to reactive oxygen species |
| Biological Process | GO:0071294 | cellular response to zinc ion |
| Biological Process | GO:0071585 | detoxification of cadmium ion |
| Biological Process | GO:0010273 | detoxification of copper ion |
| Biological Process | GO:0006112 | energy reserve metabolic process |
| Biological Process | GO:0030003 | intracellular monoatomic cation homeostasis |
| Biological Process | GO:0006882 | intracellular zinc ion homeostasis |
| Biological Process | GO:0033210 | leptin-mediated signaling pathway |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0030517 | negative regulation of axon extension |
| Biological Process | GO:0030308 | negative regulation of cell growth |
| Biological Process | GO:0050774 | negative regulation of dendrite morphogenesis |
| Biological Process | GO:2000296 | negative regulation of hydrogen peroxide catabolic process |
| Biological Process | GO:0050768 | negative regulation of neurogenesis |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0051354 | negative regulation of oxidoreductase activity |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0001934 | positive regulation of protein phosphorylation |
| Biological Process | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0032095 | regulation of response to food |
| Biological Process | GO:0019430 | removal of superoxide radicals |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0006979 | response to oxidative stress |
| Biological Process | GO:0006829 | zinc ion transport |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.