Search Results
Overview
| Uniprot ID | P37377 |
|---|---|
| Protein Name | Alpha-synuclein |
| Gene Name | Snca |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 12 | MKGLSKAKEGVVAAA |
| 21 | GVVAAAEKTKQGVAE |
| 23 | VAAAEKTKQGVAEAA |
| 32 | GVAEAAGKTKEGVLY |
| 34 | AEAAGKTKEGVLYVG |
| 43 | GVLYVGSKTKEGVVH |
| 45 | LYVGSKTKEGVVHGV |
| 58 | GVTTVAEKTKEQVTN |
| 6 | **MDVFMKGLSKAKE |
| 60 | TTVAEKTKEQVTNVG |
| 96 | AAATGFVKKDQMGKG |
Function
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity)
Protein Sequence
10
MDVFMKGLSK
20
AKEGVVAAAE
30
KTKQGVAEAA
40
GKTKEGVLYV
50
GSKTKEGVVH
60
GVTTVAEKTK
70
EQVTNVGGAV
80
VTGVTAVAQK
90
TVEGAGNIAA
100
ATGFVKKDQM
110
GKGEEGYPQE
120
GILEDMPVDP
130
SSEAYEMPSE
140
EGYQDYEPEA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0042417 | dopamine metabolic process |
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0043679 | axon terminus |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030659 | cytoplasmic vesicle membrane |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0016234 | inclusion body |
| Cellular Component | GO:0097413 | Lewy body |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005640 | nuclear outer membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0031092 | platelet alpha granule membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0005840 | ribosome |
| Cellular Component | GO:0099512 | supramolecular fiber |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0043195 | terminal bouton |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0043014 | alpha-tubulin binding |
| Molecular Function | GO:0050544 | arachidonate binding |
| Molecular Function | GO:0048487 | beta-tubulin binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005507 | copper ion binding |
| Molecular Function | GO:1903136 | cuprous ion binding |
| Molecular Function | GO:0004869 | cysteine-type endopeptidase inhibitor activity |
| Molecular Function | GO:0070840 | dynein complex binding |
| Molecular Function | GO:0008047 | enzyme activator activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0004857 | enzyme inhibitor activity |
| Molecular Function | GO:0008198 | ferrous iron binding |
| Molecular Function | GO:0042393 | histone binding |
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019894 | kinesin binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0016491 | oxidoreductase activity |
| Molecular Function | GO:0043274 | phospholipase binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0051219 | phosphoprotein binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0140311 | protein sequestering activity |
| Molecular Function | GO:0000149 | SNARE binding |
| Molecular Function | GO:0048156 | tau protein binding |
| Molecular Function | GO:0141108 | transporter regulator activity |
| Molecular Function | GO:0015631 | tubulin binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0008344 | adult locomotory behavior |
| Biological Process | GO:1990000 | amyloid fibril formation |
| Biological Process | GO:0048148 | behavioral response to cocaine |
| Biological Process | GO:0071280 | cellular response to copper ion |
| Biological Process | GO:0044344 | cellular response to fibroblast growth factor stimulus |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0042416 | dopamine biosynthetic process |
| Biological Process | GO:0060079 | excitatory postsynaptic potential |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0060291 | long-term synaptic potentiation |
| Biological Process | GO:0061024 | membrane organization |
| Biological Process | GO:0001774 | microglial cell activation |
| Biological Process | GO:0042775 | mitochondrial ATP synthesis coupled electron transport |
| Biological Process | GO:0007006 | mitochondrial membrane organization |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:1904715 | negative regulation of chaperone-mediated autophagy |
| Biological Process | GO:0045963 | negative regulation of dopamine metabolic process |
| Biological Process | GO:0051585 | negative regulation of dopamine uptake involved in synaptic transmission |
| Biological Process | GO:0045920 | negative regulation of exocytosis |
| Biological Process | GO:0031115 | negative regulation of microtubule polymerization |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0051622 | negative regulation of norepinephrine uptake |
| Biological Process | GO:0010642 | negative regulation of platelet-derived growth factor receptor signaling pathway |
| Biological Process | GO:0051612 | negative regulation of serotonin uptake |
| Biological Process | GO:0070495 | negative regulation of thrombin-activated receptor signaling pathway |
| Biological Process | GO:0006638 | neutral lipid metabolic process |
| Biological Process | GO:0006644 | phospholipid metabolic process |
| Biological Process | GO:0045807 | positive regulation of endocytosis |
| Biological Process | GO:0045921 | positive regulation of exocytosis |
| Biological Process | GO:1903285 | positive regulation of hydrogen peroxide catabolic process |
| Biological Process | GO:0050729 | positive regulation of inflammatory response |
| Biological Process | GO:0060732 | positive regulation of inositol phosphate biosynthetic process |
| Biological Process | GO:0001956 | positive regulation of neurotransmitter secretion |
| Biological Process | GO:1904377 | positive regulation of protein localization to cell periphery |
| Biological Process | GO:0001921 | positive regulation of receptor recycling |
| Biological Process | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol |
| Biological Process | GO:0035543 | positive regulation of SNARE complex assembly |
| Biological Process | GO:0050806 | positive regulation of synaptic transmission |
| Biological Process | GO:0051259 | protein complex oligomerization |
| Biological Process | GO:0031648 | protein destabilization |
| Biological Process | GO:0051262 | protein tetramerization |
| Biological Process | GO:0031623 | receptor internalization |
| Biological Process | GO:0050812 | regulation of acyl-CoA biosynthetic process |
| Biological Process | GO:0014059 | regulation of dopamine secretion |
| Biological Process | GO:0014048 | regulation of glutamate secretion |
| Biological Process | GO:0040012 | regulation of locomotion |
| Biological Process | GO:0048169 | regulation of long-term neuronal synaptic plasticity |
| Biological Process | GO:0043030 | regulation of macrophage activation |
| Biological Process | GO:0070507 | regulation of microtubule cytoskeleton organization |
| Biological Process | GO:0048168 | regulation of neuronal synaptic plasticity |
| Biological Process | GO:0046928 | regulation of neurotransmitter secretion |
| Biological Process | GO:0051621 | regulation of norepinephrine uptake |
| Biological Process | GO:1905606 | regulation of presynapse assembly |
| Biological Process | GO:2000377 | regulation of reactive oxygen species metabolic process |
| Biological Process | GO:0042220 | response to cocaine |
| Biological Process | GO:1904307 | response to desipramine |
| Biological Process | GO:0070555 | response to interleukin-1 |
| Biological Process | GO:0010040 | response to iron(II) ion |
| Biological Process | GO:0032496 | response to lipopolysaccharide |
| Biological Process | GO:0032026 | response to magnesium ion |
| Biological Process | GO:0034341 | response to type II interferon |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0035493 | SNARE complex assembly |
| Biological Process | GO:0050808 | synapse organization |
| Biological Process | GO:0001963 | synaptic transmission, dopaminergic |
| Biological Process | GO:0048488 | synaptic vesicle endocytosis |
| Biological Process | GO:0016079 | synaptic vesicle exocytosis |
| Biological Process | GO:0016082 | synaptic vesicle priming |
| Biological Process | GO:0048489 | synaptic vesicle transport |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.