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Overview

Uniprot IDP37397
Protein NameCalponin-3
Gene NameCnn3
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
156 TRRFDEGKLKAGQSV
158 RFDEGKLKAGQSVIG
17 YGLSAEVKNKIASKY
23 VKNKIASKYDQQAEE
256 TNKVASQKGMSVYGL
6 **MTHFNKGPSYGLS

Function

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity

Protein Sequence

10 MTHFNKGPSY 20 GLSAEVKNKI 30 ASKYDQQAEE 40 DLRNWIEEVT 50 GMGIGTNFQL 60 GLKDGIILCE 70 LINKLQPGSV 80 KKVNESSLNW 90 PQLENIGNFI 100 KAIQAYGMKP 110 HDIFEANDLF 120 ENGNMTQVQT 130 TLVALAGLAK 140 TKGFHTTIDI 150 GVKYAEKQTR 160 RFDEGKLKAG 170 QSVIGLQMGT 180 NKCASQAGMT 190 AYGTRRHLYD 200 PKMQTDKPFD 210 QTTISLQMGT 220 NKGASQAGMS 230 APGTRRDIYD 240 QKLTLQPVDN 250 STISLQMGTN 260 KVASQKGMSV 270 YGLGRQVYDP 280 KYCAAPTEPV 290 IHNGSQGTGT 300 NGSEISDSDY 310 QAEYPDEYHG 320 EYPDEYPREY 330 QYGDDQGIDY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005884 actin filament
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030425 dendrite
Cellular Component GO:0043197 dendritic spine
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005874 microtubule
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0098794 postsynapse
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Biological Process GO:0007015 actin filament organization
Biological Process GO:0031032 actomyosin structure organization
Biological Process GO:0030855 epithelial cell differentiation
Biological Process GO:0032780 negative regulation of ATP-dependent activity

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.